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Alomone Labs, LTD
alpha 2A-Adrenergic Receptor (extracellular) Polyclonal Antibody
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alpha 2A-Adrenergic Receptor (extracellular) Antibody (AAR-020-200UL) in IHC (F)
Expression of alpha 2A-Adrenoreceptor in rat hypothalamus - Immunohistochemical staining of rat ventromedial hypothalamus free floating frozen section using Anti- alpha 2A-Adrenergic Receptor (extracellular) Antibody (#AAR-020), (1:250). A. alpha 2A-Adrenoreceptor staining (green) appears in astrocytic fibers (arrows) originating from the wall of the 3rd ventricle (3rd V). B. DAPI is used as the counterstai... View More
产品信息
AAR-020-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)DAGNSSWNGTEAPG, corresponding to amino acid residues 7-20 of rat alpha 2A-adrenoceptor, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR; Alpha-2D adrenergic receptor; alpha2A-adrenergic receptor; CA2-47; OTTHUMP00000058849; subtype alpha2-C10
基因别名: Adra-2; Adra-2a; Adra2a; alpha(2A)AR; alpha2-C10; alpha2A; alpha2A-AR; AW122659; CA2-47; RATRG20; RG20
UniProt ID: (Mouse) Q01338, (Rat) P22909
Entrez Gene ID: (Mouse) 11551, (Rat) 25083
adrenergic receptor activity
alpha2-adrenergic receptor activity
protein kinase binding
alpha-2C adrenergic receptor binding
thioesterase binding
heterotrimeric G-protein binding
protein homodimerization activity
protein heterodimerization activity
epinephrine binding
norepinephrine binding
G-protein coupled receptor
positive regulation of cytokine production
acute inflammatory response
DNA replication
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
cell-cell signaling
female pregnancy
negative regulation of norepinephrine secretion
positive regulation of cell migration
negative regulation of cAMP biosynthetic process
activation of protein kinase activity
activation of protein kinase B activity
cellular response to hormone stimulus
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
glucose homeostasis
fear response
positive regulation of MAP kinase activity
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of vasodilation
negative regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
thermoception
negative regulation of lipid catabolic process
positive regulation of membrane protein ectodomain proteolysis
negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of uterine smooth muscle contraction
adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
phospholipase C-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
positive regulation of wound healing
regulation of smooth muscle contraction
signal transduction
regulation of vasoconstriction
platelet activation
