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Alomone Labs, LTD
alpha 2C-Adrenergic Receptor (extracellular) Polyclonal Antibody
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alpha 2C-Adrenergic Receptor (extracellular) Antibody (AAR-022-200UL) in IHC (P)
Expression of alpha 2C-Adrenoreceptor in rat kidney - Immunohistochemical staining of rat kidney paraffin embedded sections using Anti- alpha 2C-Adrenergic Receptor (extracellular) Antibody (#AAR-022), (1:100). alpha 2C-Adrenoreceptor is expressed in both proximal (PT) and distal (DT) renal tubules and in the collecting ducts (CD). Hematoxilin is used as the counterstain.
产品信息
AAR-022-200UL
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)RRPDGAAYPQ*SGLNDE, corresponding to amino acid residues 192-207 of rat alpha 2C-adrenoceptor with replacement of cysteine 202 (C202) with serine (*S), 2nd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adra 2c; Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; Alpha 2CAR; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2C-AR; alpha-2CAR; alpha2 AR C4; alpha2 C4
基因别名: Adra2c
UniProt ID: (Rat) P22086
Entrez Gene ID: (Rat) 24175
G-protein coupled receptor signaling pathway
female pregnancy
platelet activation
activation of protein kinase B activity
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
positive regulation of vasoconstriction
regulation of sensory perception of pain
negative regulation of uterine smooth muscle contraction
activation of MAPK activity by adrenergic receptor signaling pathway
