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alpha Actinin 1 Antibody (PA5-109306) in ICC/IF
Immunofluorescent analysis of alpha Actinin in MG-63 cells (green). Samples were fixed in paraformaldehyde and permeabilised with 0.25% Triton X100/PBS, incubated with alpha Actinin polyclonal antibody (Product # PA5-109306), followed by DAPI (blue).
产品信息
PA5-109306
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within Human alpha Actinin aa 388-619
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2854717
产品详细信息
Positive Control: A431, rat colon tissue lysates, mouse colon tissue lysates, MG-63, SiHa, human colon cancer tissue, human kidney tissue, mouse colon tissue.
靶标信息
Alpha Actinin 1 belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: actinin 1 smooth muscle; actinin, alpha 1; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; F-actin cross-linking protein; FLJ40884; FLJ54432; Non-muscle alpha-actinin-1
基因别名: ACTN1; BDPLT15
UniProt ID: (Human) P12814
Entrez Gene ID: (Human) 87
platelet degranulation
actin filament organization
platelet activation
platelet formation
platelet morphogenesis
regulation of apoptotic process
focal adhesion assembly
actin filament bundle assembly
negative regulation of cellular component movement
actin filament network formation
actin crosslink formation
platelet aggregation
regulation of nucleic acid-templated transcription
