Invitrogen

alpha Actinin 4 Polyclonal Antibody

alpha Actinin 4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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alpha Actinin 4 Antibody (PA5-118929) in IHC (P)

Immunohistochemistry analysis of alpha Actinin 4 in paraffin-embedded Human Colorectal cancer tissue. Samples were incubated with polyclonal antibody (Product # PA5-118929) at a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.

alpha Actinin 4 Antibody in Western Blot (WB)

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产品信息

PA5-118929

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-2 µg/mL

免疫组化（石蜡） (IHC (P))

5-20 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein Actinin Alpha 4. The antigen corresponds to amino acid range 1-269 of the target protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C

运输条件

Wet ice

AB_2903429

靶标信息

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。