Product References
Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology.
NPJ Parkinson's disease
Ng XY,Wu Y,Lin Y,Yaqoob SM,Greene LE,De Camilli P,Cao M
MA1-064 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (PFA fixed), Immunoprecipitation, Inhibition Assays, Western Blot to report that auxilin knockout (Aux-KO) mice display dystrophic changes of a subset of nigrostriatal DAergic terminals similar to those of SJ1-KIRQ mice.
Wed Feb 15 00:00:00 UTC 2023
Endocytosis in the axon initial segment maintains neuronal polarity.
Nature
Eichel K,Uenaka T,Belapurkar V,Lu R,Cheng S,Pak JS,Taylor CA,Südhof TC,Malenka R,Wernig M,Özkan E,Perrais D,Shen K
MA1-064 was used in Immunocytochemistry-immunoflourescence to reveal a conserved endocytic clearance mechanism in the AIS to maintain neuronal polarity by reinforcing axonal and dendritic compartment membrane boundaries.
Thu Sep 01 00:00:00 UTC 2022
Endocytosis in the axon initial segment maintains neuronal polarity.
Nature
Eichel K,Uenaka T,Belapurkar V,Lu R,Cheng S,Pak JS,Taylor CA,Südhof TC,Malenka R,Wernig M,Özkan E,Perrais D,Shen K
MA1-064 was used in Immunocytochemistry-immunoflourescence to reveal a conserved endocytic clearance mechanism in the AIS to maintain neuronal polarity by reinforcing axonal and dendritic compartment membrane boundaries.
Thu Sep 01 00:00:00 UTC 2022
Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates α5β1 integrin endocytosis.
Scientific reports
Caliva MJ,Yang WS,Young-Robbins S,Zhou M,Yoon H,Matter ML,Grimes ML,Conrads T,Ramos JW
MA1-064 was used in Proximity Ligation Assay (PLA) to support a novel endosomal role for PEA-15 in control of endosomal trafficking of integrins through an association with the β1 integrin and clathrin complexes, and thereby regulation of cell motility.
Wed Oct 06 00:00:00 UTC 2021
A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.
Developmental cell
Puri C,Manni MM,Vicinanza M,Hilcenko C,Zhu Y,Runwal G,Stamatakou E,Menzies FM,Mamchaoui K,Bitoun M,Rubinsztein DC
MA1-064 was used in Immunocytochemistry to describe events critical for autophagosome formation.
Mon Apr 20 00:00:00 UTC 2020
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Neurobiology of disease
Heaton GR,Landeck N,Mamais A,Nalls MA,Nixon-Abell J,Kumaran R,Beilina A,Pellegrini L,Li Y,Harvey K,Cookson MR
Published figure using alpha Adaptin monoclonal antibody (Product # MA1-064) in Immunocytochemistry
Wed Jul 01 00:00:00 UTC 2020
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Neurobiology of disease
Heaton GR,Landeck N,Mamais A,Nalls MA,Nixon-Abell J,Kumaran R,Beilina A,Pellegrini L,Li Y,Harvey K,Cookson MR
Published figure using alpha Adaptin monoclonal antibody (Product # MA1-064) in Immunocytochemistry
Wed Jul 01 00:00:00 UTC 2020
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Neurobiology of disease
Heaton GR,Landeck N,Mamais A,Nalls MA,Nixon-Abell J,Kumaran R,Beilina A,Pellegrini L,Li Y,Harvey K,Cookson MR
Published figure using alpha Adaptin monoclonal antibody (Product # MA1-064) in Immunocytochemistry
Wed Jul 01 00:00:00 UTC 2020
Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the httQ140/Q140 mouse model of Huntington's disease.
Neurobiology of disease
McAdam RL,Morton A,Gordon SL,Alterman JF,Khvorova A,Cousin MA,Smillie KJ
MA1-064 was used in Immunoprecipitation to study the pathogenesis of Huntington's disease through observation of medium spiny neurons response to intense neuronal activity.
Sat Feb 01 00:00:00 UTC 2020
Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Journal of neurochemistry
Wijasa TS,Sylvester M,Brocke-Ahmadinejad N,Schwartz S,Santarelli F,Gieselmann V,Klockgether T,Brosseron F,Heneka MT
MA1-064 was used in Western Blot to investigate S-nitrosylation in synaptosomal proteins isolated from APP/PS1 model mice in comparison to wild type and NOS2-/- mice, as well as human control, mild cognitive impairment and Alzheimer's disease brain tissues.
Sun Mar 01 00:00:00 UTC 2020
Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
La TM,Tachibana H,Li SA,Abe T,Seiriki S,Nagaoka H,Takashima E,Takeda T,Ogawa D,Makino SI,Asanuma K,Watanabe M,Tian X,Ishibe S,Sakane A,Sasaki T,Wada J,Takei K,Yamada H
MA1-064 was used in Immunocytochemistry to suggest that dynamin 1 supports the microtubule bundle formation and participates in the stabilization of microtubules.
Tue Dec 01 00:00:00 UTC 2020
The TRAPP complex mediates secretion arrest induced by stress granule assembly.
The EMBO journal
Zappa F,Wilson C,Di Tullio G,Santoro M,Pucci P,Monti M,D'Amico D,Pisonero-Vaquero S,De Cegli R,Romano A,Saleem MA,Polishchuk E,Failli M,Giaquinto L,De Matteis MA
MA1-064 was used in Immunocytochemistry to identify the TRAPP complex as a component of a branch of the integrated stress response that impinges on the early secretory pathway.
Tue Oct 01 00:00:00 UTC 2019
Neuron/Glial Antigen 2-Type VI Collagen Interactions During Murine Temporomandibular Joint Osteoarthritis.
Scientific reports
Yotsuya M,Bertagna AE,Hasan N,Bicknell S,Sato T,Reed DA
MA1-064 was used in Immunohistochemistry to define the temporospatial dynamics of neuron/glia antigen 2-type VI collagen interactions during the progression of temporomandibular joint osteoarthritis.
Fri Jan 11 00:00:00 UTC 2019
Coupling of microtubule motors with AP-3 generated organelles in axons by NEEP21 family member calcyon.
Molecular biology of the cell
Shi L,Hines T,Bergson C,Smith D
MA1-064 was used in Western Blotting to identify a novel mechanism regulating late endosomes and lysosome-related organelles transport based on the coordinated coupling of microtubule motors and vesicle coat proteins to the neuron-enriched, transmembrane protein calcyon.
Wed Aug 15 00:00:00 UTC 2018
An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients.
Frontiers in molecular neuroscience
Poulsen ET,Iannuzzi F,Rasmussen HF,Maier TJ,Enghild JJ,Jørgensen AL,Matrone C
MA1064 was used in immunocytochemistry and western blot to study amyloid precursor protein Tyr phosphorylation in mouse model of Alzheimer's disease
Mon Sep 25 00:00:00 UTC 2023
An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients.
Frontiers in molecular neuroscience
Poulsen ET,Iannuzzi F,Rasmussen HF,Maier TJ,Enghild JJ,Jørgensen AL,Matrone C
MA1064 was used in immunocytochemistry and western blot to study amyloid precursor protein Tyr phosphorylation in mouse model of Alzheimer's disease
Mon Sep 25 00:00:00 UTC 2023
An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients.
Frontiers in molecular neuroscience
Poulsen ET,Iannuzzi F,Rasmussen HF,Maier TJ,Enghild JJ,Jørgensen AL,Matrone C
MA1064 was used in immunocytochemistry and western blot to study amyloid precursor protein Tyr phosphorylation in mouse model of Alzheimer's disease
Mon Sep 25 00:00:00 UTC 2023
Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors.
Traffic (Copenhagen, Denmark)
Stoneham CA,Singh R,Jia X,Xiong Y,Guatelli J
MA1-064 was used in Immunocytochemistry to propose that the flexibility with which Vpu binds AP complexes broadens the range of cellular targets that it can misdirect to the virus' advantage.
Tue Aug 01 00:00:00 UTC 2017
Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags.
Journal of neuroscience methods
Wijasa TS,Sylvester M,Brocke-Ahmadinejad N,Kummer MP,Brosseron F,Gieselmann V,Heneka MT
MA1-064 was used in Western Blotting to describe a protocol for quantitative proteomics of nitrosylation on synaptosomal proteins.
Wed Nov 01 00:00:00 UTC 2017
Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells.
Nature cell biology
Sochacki KA,Dickey AM,Strub MP,Taraska JW
MA1-064 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (PFA fixed), Immunoprecipitation, Inhibition Assays, Western Blot to propose that endocytosis is driven by the recruitment, reorganization and loss of proteins within these partitioned nanoscale zones.
Sat Apr 01 00:00:00 UTC 2017
Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.
Nature structural & molecular biology
De Franceschi N,Arjonen A,Elkhatib N,Denessiouk K,Wrobel AG,Wilson TA,Pouwels J,Montagnac G,Owen DJ,Ivaska J
MA1-064 was used in immunocytochemistry to monitor the interaction beteween integrin alpha chain and AP2 and how selective integrin endocytosis drives the interaction
Mon Feb 01 00:00:00 UTC 2016
Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis.
EMBO reports
Wang C,Wang Y,Hu M,Chai Z,Wu Q,Huang R,Han W,Zhang CX,Zhou Z
MA1-064 was used in immunocytochemistry to characterize inhibition of clathrin-mediated and bulk endocytosis by synaptotagmin-11
Fri Jan 01 00:00:00 UTC 2016
αTAT1 downregulation induces mitotic catastrophe in HeLa and A549 cells.
Cell death discovery
Chien JY,Tsen SD,Chien CC,Liu HW,Tung CY,Lin CH
MA1064 was used in immunocytochemistry to assess the effect of three alpha-tubulin acetyltransferase 1-specific shRNAs on proliferation and morphology in HeLa and A549 cell lines
Tue Aug 23 00:00:00 UTC 2016
Endophilin marks and controls a clathrin-independent endocytic pathway.
Nature
Boucrot E,Ferreira AP,Almeida-Souza L,Debard S,Vallis Y,Howard G,Bertot L,Sauvonnet N,McMahon HT
MA1-064 was used in immunocytochemistry and western blot to identify and characterize a new endocytic route that is called fast endophilin-mediated endocytosis.
Thu Jan 22 00:00:00 UTC 2015
Endophilin marks and controls a clathrin-independent endocytic pathway.
Nature
Boucrot E,Ferreira AP,Almeida-Souza L,Debard S,Vallis Y,Howard G,Bertot L,Sauvonnet N,McMahon HT
MA1-064 was used in immunocytochemistry and western blot to identify and characterize a new endocytic route that is called fast endophilin-mediated endocytosis.
Thu Jan 22 00:00:00 UTC 2015
The clathrin-binding and J-domains of GAK support the uncoating and chaperoning of clathrin by Hsc70 in the brain.
Journal of cell science
Park BC,Yim YI,Zhao X,Olszewski MB,Eisenberg E,Greene LE
MA1-064 was used in Immunocytochemistry-immunoflourescence to study the mechanism by which cyclin-G-associated kinase supports the uncoating and chaperoning of clathrin by Hsc70 in the brain.
Thu Oct 15 00:00:00 UTC 2015
Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.
The EMBO journal
Vehlow A,Soong D,Vizcay-Barrena G,Bodo C,Law AL,Perera U,Krause M
MA1-064 was used in immunocytochemistry to study F-actin-dependent endocytosis of the EGFR and the novel modulatory roles played by endophilin, lamellipodin, and mena
Wed Oct 16 00:00:00 UTC 2013
Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.
Journal of cell science
Park RJ,Shen H,Liu L,Liu X,Ferguson SM,De Camilli P
MA1-064 was used in immunocytochemistry to study the off-target activity of dynamin inhibitors using cells deleted for dynamins 1-3
Fri Nov 15 00:00:00 UTC 2013
Releasable SNAP-tag probes for studying endocytosis and recycling.
ACS chemical biology
Cole NB,Donaldson JG
MA1-064 was used in immunocytochemistry to evaluated a modified SNAP-tag protocol for the study of endocytosis and recycling
Fri Mar 16 00:00:00 UTC 2012
EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization.
Molecular biology of the cell
Morén B,Shah C,Howes MT,Schieber NL,McMahon HT,Parton RG,Daumke O,Lundmark R
MA1-064 was used in immunocytochemistry to study the mechanism by which the dynamin-related ATPase regulates caveolin dynamics
Sun Apr 01 00:00:00 UTC 2012
Disabled-2 protein facilitates assembly polypeptide-2-independent recruitment of cystic fibrosis transmembrane conductance regulator to endocytic vesicles in polarized human airway epithelial cells.
The Journal of biological chemistry
Cihil KM,Ellinger P,Fellows A,Stolz DB,Madden DR,Swiatecka-Urban A
MA1-064 was used in western blot to study the role of the disabled-2 protein in cystic fibrosis transmembrane conductance regulator levels in human airway epithelial cells
Fri Apr 27 00:00:00 UTC 2012
Mistargeting of SH3TC2 away from the recycling endosome causes Charcot-Marie-Tooth disease type 4C.
Human molecular genetics
Roberts RC,Peden AA,Buss F,Bright NA,Latouche M,Reilly MM,Kendrick-Jones J,Luzio JP
MA1-064 was used in immunocytochemistry to investigate the causal role of SH3TC2 localization in the pathogenesis of Charcot-Marie-Tooth disease type 4C
Mon Mar 15 00:00:00 UTC 2010
Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex.
Proceedings of the National Academy of Sciences of the United States of America
Schmidt MR,Maritzen T,Kukhtina V,Higman VA,Doglio L,Barak NN,Strauss H,Oschkinat H,Dotti CG,Haucke V
MA1-064 was used in immunocytochemistry to study the regulatory role of a Gadkin/AP-1/kinesin KIF5 complex in endosomal membrane trafficing
Tue Sep 08 00:00:00 UTC 2009
Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.
Journal of cell science
Hood FE,Royle SJ
MA1-064 was used in immunocytochemistry to investigate the important roles of two clathrin heavy chains in endocytosis and mitosis
Wed Jul 01 00:00:00 UTC 2009
Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient mice.
Traffic (Copenhagen, Denmark)
Ameen N,Apodaca G
MA1-064 was used in western blot to investigate the role of myosin in CFTR apical endocytosis and enterocyte brush border
Wed Aug 01 00:00:00 UTC 2007
Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells.
Molecular & cellular proteomics : MCP
Zanardi A,Giorgetti L,Botrugno OA,Minucci S,Milani P,Pelicci PG,Carbone R
MA1-064 was used in immunocytochemistry to develop a new method called immunocell-array for investigating multiple signaling pathways in mammalian cells
Tue May 01 00:00:00 UTC 2007
Death-receptor activation halts clathrin-dependent endocytosis.
Proceedings of the National Academy of Sciences of the United States of America
Austin CD,Lawrence DA,Peden AA,Varfolomeev EE,Totpal K,De Mazière AM,Klumperman J,Arnott D,Pham V,Scheller RH,Ashkenazi A
MA1-064 was used in immunoprecipitation to investigate the effect of death receptor activation on clathrin-dependent endocytosis and its influence on cellular apoptosis.
Wed Jul 05 00:00:00 UTC 2006
SPG3A protein atlastin-1 is enriched in growth cones and promotes axon elongation during neuronal development.
Human molecular genetics
Zhu PP,Soderblom C,Tao-Cheng JH,Stadler J,Blackstone C
MA1-064 was used in immunocytochemistry to study the role of the SPG3A protein atlastin-1 in neural growth cones and axon elongation
Sat Apr 15 00:00:00 UTC 2006
Recruitment of clathrin onto endosomes by the Tom1-Tollip complex.
Biochemical and biophysical research communications
Katoh Y,Imakagura H,Futatsumori M,Nakayama K
MA1-064 was used in immunocytochemistry to study the role of the Tom1-Tollip complex in recruiting clathrin to endosomes
Fri Mar 03 00:00:00 UTC 2006
Exchange of clathrin, AP2 and epsin on clathrin-coated pits in permeabilized tissue culture cells.
Journal of cell science
Yim YI,Scarselletta S,Zang F,Wu X,Lee DW,Kang YS,Eisenberg E,Greene LE
MA1-064 was used in immunocytochemistry to investigate the mechanism of exchange of clathrin, AP2 and epsin on clathrin-coated pits in permeabilized tissue culture cells
Wed Jun 01 00:00:00 UTC 2005
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Molecular biology of the cell
Janvier K,Bonifacino JS
MA1-064 was used in immunocytochemistry to study the roles of adaptor protein complexes.
Thu Sep 01 00:00:00 UTC 2005
Highly cooperative control of endocytosis by clathrin.
Molecular biology of the cell
Moskowitz HS,Yokoyama CT,Ryan TA
MA1-064 was used in immunocytochemistry to study the role of clathrin during endocytosis.
Fri Apr 01 00:00:00 UTC 2005
SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling.
Journal of immunology (Baltimore, Md. : 1950)
Wang Y,Keogh RJ,Hunter MG,Mitchell CA,Frey RS,Javaid K,Malik AB,Schurmans S,Tridandapani S,Marsh CB
MA1-064 was used in western blot to investigate the mechanism for the regulation of macrophage colony-stimulating factor signaling by SHIP2
Wed Dec 01 00:00:00 UTC 2004
In vitro formation of recycling vesicles from endosomes requires adaptor protein-1/clathrin and is regulated by rab4 and the connector rabaptin-5.
Molecular biology of the cell
Pagano A,Crottet P,Prescianotto-Baschong C,Spiess M
MA1-064 was used in immunoprecipitation to study the role of AP-1/clathrin in the receptor recycling by endosomes.
Mon Nov 01 00:00:00 UTC 2004
RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery.
Molecular biology of the cell
Engqvist-Goldstein AE,Zhang CX,Carreno S,Barroso C,Heuser JE,Drubin DG
MA1-064 was used in immunocytochemistry to investigate the role of Huntingtin interacting protein 1R at the interface between the actin cytoskeleton and the endocytic machinery
Thu Apr 01 00:00:00 UTC 2004
Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits.
Nature cell biology
Merrifield CJ,Feldman ME,Wan L,Almers W
MA1-064 was used in immunocytochemistry to study the recruitment of actin and dynamin in single clathrin-coated pits by imaging
Sun Sep 01 00:00:00 UTC 2002
The tripartite motif family identifies cell compartments.
The EMBO journal
Reymond A,Meroni G,Fantozzi A,Merla G,Cairo S,Luzi L,Riganelli D,Zanaria E,Messali S,Cainarca S,Guffanti A,Minucci S,Pelicci PG,Ballabio A
MA1-064 was used in immunocytochemistry to study the role of tripartite motif proteins in cell compartmentation
Tue May 01 00:00:00 UTC 2001
Nucleocytoplasmic shuttling of endocytic proteins.
The Journal of cell biology
Vecchi M,Polo S,Poupon V,van de Loo JW,Benmerah A,Di Fiore PP
MA1-064 was used in Immunocytochemistry-immunoflourescence to identify an unexpected link between endocytosis and transcription.
Mon Jun 25 00:00:00 UTC 2001
The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro.
The Journal of cell biology
Engqvist-Goldstein AE,Warren RA,Kessels MM,Keen JH,Heuser J,Drubin DG
MA1-064 was used in Immunocytochemistry-immunoflourescence to show Hip1R's properties suggest an early endocytic function at the interface between clathrin, F-actin, and lipids.
Mon Sep 17 00:00:00 UTC 2001
100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding properties.
The Journal of cell biology
Wong DH,Brodsky FM
MA1-064 was used in immunocytochemistry to study coat protein membrane binding properties in the Golgi region
Mon Jun 01 00:00:00 UTC 1992
