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alpha-Cardiac Actin Antibody (PA5-85863) in WB
Western blot analysis was performed on whole cell extract (30 µg lysate) of C2C12 (Lane 1), HeLa (Lane 2), Mouse heart (Lane 3), and Mouse liver (Lane 4). The blot was probed with Anti-alpha-Cardiac Actin Polyclonal Antibody (Product # PA5-85863, 1:1000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 42 kDa band corresponding to alpha-Cardiac Actin was detected in Mouse heart tissue and myoblast cell line a... View More
产品信息
PA5-85863
产品规格
种属反应
Human,
Mouse,
Rat,
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within Human alpha-Actin (cardiac actin) aa 1-50
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% Glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2802664
靶标信息
ACTC1 are part of actins, which are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: actin alpha cardiac; actin alpha cardiac 1; Actin, alpha cardiac muscle 1; actin, alpha, cardiac 1; alpha-actin cardiac; Alpha-cardiac actin; alphac-actin
基因别名: ACTC; Actc-1; ACTC1; ASD5; CMD1R; CMH11; LVNC4
UniProt ID: (Human) P68032, (Mouse) P68033, (Rat) P68035
Entrez Gene ID: (Human) 70, (Mouse) 11464, (Rat) 29275
apoptotic process
positive regulation of gene expression
actin filament-based movement
muscle filament sliding
skeletal muscle thin filament assembly
actomyosin structure organization
actin-myosin filament sliding
response to drug
negative regulation of apoptotic process
response to ethanol
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
heart contraction
cardiac muscle contraction
mesenchyme migration
metabolic process
actin-mediated cell contraction
