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产品信息
MA5-14963
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
T.44.7
抗原
Synthetic peptide corresponding to the carboxy-terminal sequence of human a-N-Catenin
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_10987198
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other -alpha-catenin family members.
靶标信息
The catenins (alpha, beta, and gamma) are cytoplasmic proteins found in varying abundance in many developing and adult tissues. Catenins bind directly or indirectly to the conserved cytoplasmic tail domain of the cell adhesion cadherins. The association of catenins to cadherins produces a complex, which is linked to the actin filament network. Catenins/cadherin complexes play an important role in mediating cell adhesion, transduction of cell-cell contact positional signals to the cell interior, and may play a crucial role in cell differentiation. Alpha-Catenin (CAP102, 102 kDa), originally described as an E-cadherin associated protein, has been shown to associate with other members of the cadherin family members, N-cadherin and P-cadherin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha N-catenin; alpha(N)-catenin; Alpha-catenin-related protein; alpha-N-catenin; cadherin associated protein; cadherin-associated protein, related; cancer/testis antigen 114; catenin (cadherin-associated protein), alpha 2; catenin alpha 2; Catenin alpha-2; cerebellar deficient folia; DKFZp686H02198; OTTHUMP00000216460; OTTHUMP00000216462
基因别名: AI481747; CAP-R; CAPR; Catna; Catna2; cdf; chp; CT114; CTNNA2; CTNR
UniProt ID: (Human) P26232, (Mouse) Q61301
Entrez Gene ID: (Human) 1496, (Mouse) 12386, (Rat) 297357
cytoskeleton organization
axonogenesis
single organismal cell-cell adhesion
radial glia guided migration of Purkinje cell
dendrite morphogenesis
brain morphogenesis
positive regulation of muscle cell differentiation
regulation of synapse structural plasticity
prepulse inhibition
cell adhesion
multicellular organism development
cell differentiation
