Invitrogen

beta-2 Adaptin Polyclonal Antibody

beta-2 Adaptin Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

beta-2 Adaptin Antibody (PA1-1066) in ICC/IF

Immunofluorescent analysis of beta-2 Adaptin was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with beta-2 Adaptin Rabbit Polyclonal Antibody (Product # PA1-1066) at 2 µg/mL in 0.1% BSA and incubated for 3 ... View More

beta-2 Adaptin Antibody in Western Blot (WB)

Product Image Gallery

产品信息

PA1-1066

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2 µg/mL

免疫细胞化学 (ICC/IF)

2 µg/mL

产品规格

种属反应

Bovine, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues I(588) H R K H L P I H H G S T D A G D S P(606) of human beta Adaptin 2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2056349

产品详细信息

PA1-1066 detects beta Adaptin 2 from human, mouse, rat, and bovine samples.

PA1-1066 has been successfully used in Western blot procedures.

The PA1-1066 immunogen is a synthetic peptide corresponding to residues I(588) H R K H L P I H H G S T D A G D S P(606) of human beta Adaptin 2.

PA1-1066 can be used with blocking peptide PEP-293.

靶标信息

Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate ~100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ~50 and ~17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: adapter-related protein complex 1 subunit beta-1; adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptin, beta 2 (beta); Adaptor protein complex AP-1 subunit beta-1; Adaptor protein complex AP-2 subunit beta; adaptor related protein complex 2, beta 1 subunit; Adaptor-related protein complex 1 subunit beta-1; Adaptor-related protein complex 2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; AP-1 complex subunit beta-1; AP-2 complex subunit beta; AP105B; beta adaptin; Beta-1-adaptin; Beta-2-adaptin; Beta-adaptin; Beta-adaptin 1; beta1-adaptin; beta2-adaptin; Clathrin assembly protein complex 1 beta large chain; Clathrin assembly protein complex 2 beta large chain; clathrin-associated / assembly / adaptor protein, large, beta 1; clathrin-associated/assembly/adaptor; clathrin-associated/assembly/adaptor protein, large, beta 1; Golgi adaptor HA1/AP1 adaptin beta subunit; Plasma membrane adaptor HA2/AP2 adaptin beta subunit; testicular tissue protein Li 22

查看更多收起

基因别名: 1300012O03Rik; ADTB2; AI788979; AP105B; AP2-BETA; AP2B1; BOS_18468; CLAPB1