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Invitrogen
beta-2 Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody (JM102-06)
产品信息
MA5-32570
产品规格
种属反应
Human,
Mouse,
Rat,
Zebrafish
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM102-06
抗原
Synthetic peptide within Human ADRB2 aa 369-400
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809847
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
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生物信息学
蛋白别名: Adrenergic beta 2- receptor surface; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; AR beta2; beta 2-AR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286
基因别名: Adrb-2; ADRB2; ADRB2R; ADRBR; B2AR; Badm; BAR; BETA2AR; Gpcr7
UniProt ID: (Human) P07550, (Mouse) P18762
Entrez Gene ID: (Human) 154, (Mouse) 11555, (Rat) 24176
G-protein alpha-subunit binding
beta2-adrenergic receptor activity
protein binding
drug binding
adenylate cyclase binding
potassium channel regulator activity
B2 bradykinin receptor binding
protein complex binding
dopamine binding
ionotropic glutamate receptor binding
protein homodimerization activity
epinephrine binding
norepinephrine binding
signal transducer activity
G-protein coupled receptor activity
adrenergic receptor activity
enzyme binding
PDZ domain binding
G-protein coupled receptor
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
diaphragm contraction
positive regulation of the force of heart contraction by epinephrine
receptor-mediated endocytosis
cell surface receptor signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
cell-cell signaling
female pregnancy
aging
positive regulation of cell proliferation
associative learning
endosome to lysosome transport
response to cold
positive regulation of sodium ion transport
negative regulation of angiogenesis
negative regulation of ossification
positive regulation of bone mineralization
positive regulation of protein ubiquitination
heat generation
response to progesterone
positive regulation of ATPase activity
response to testosterone
synaptic transmission, glutamatergic
negative regulation of urine volume
negative regulation of multicellular organism growth
wound healing
positive regulation of apoptotic process
positive regulation of potassium ion transport
positive regulation of MAPK cascade
response to estrogen
estrous cycle
bone resorption
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of smooth muscle contraction
positive regulation of skeletal muscle tissue growth
negative regulation of inflammatory response
brown fat cell differentiation
regulation of calcium ion transport
regulation of sensory perception of pain
excitatory postsynaptic potential
cellular response to hypoxia
response to dexamethasone
response to monoamine
adenylate cyclase-activating adrenergic receptor signaling pathway
negative regulation of platelet aggregation
liver regeneration
positive regulation of autophagosome maturation
positive regulation of lipophagy
positive regulation of mitophagy in response to mitochondrial depolarization
regulation of systemic arterial blood pressure by norepinephrine-epinephrine
regulation of sodium ion transport
regulation of smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
regulation of vasodilation
positive regulation of heart contraction
adrenergic receptor signaling pathway
mitophagy in response to mitochondrial depolarization
response to hypoxia
liver development
