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Alomone Labs, LTD
beta 3-Adrenergic Receptor (extracellular) Polyclonal Antibody
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beta 3-Adrenergic Receptor (extracellular) Antibody (AAR-017-200UL) in IHC
Expression of beta 3-Adrenoceptor in rat hippocampus - Immunohistochemical staining of rat hippocampal dentate gyrus using Anti- beta 3-Adrenergic Receptor (extracellular) Antibody (#AAR-017), (1:100), (green). beta 3-Adrenoceptor is strongly expressed in the hilus (H) and in the outer molecular layer (arrows). The distribution overlaps the entire layers, but is not restricted to nerve cells (stained red wi... View More
产品信息
AAR-017-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DAEAQESH*SNPRC, corresponding to amino acid residues 180-192 of mouse ADRB3with replacement of cysteine 186 (C186) with serine (*S), 2nd extracellular loop
偶联物
形式
Lyophilized
浓度
0.75 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
beta 3 Adrenergic Receptor is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Beta adrenergic receptors are involved in the epinephrine and norepinephrine-induced activation of adenylate cyclase through the action of G proteins. beta 3 Adrenergic Receptor expression has been documented in adipose tissues, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of this protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adrenergic receptor, beta 3; adrenergic, beta-3-, receptor; beta 3 adrenoceptor; beta 3-AR; Beta-3 adrenergic receptor; Beta-3 adrenoceptor; Beta-3 adrenoreceptor; Beta-3 AR; beta3-adrenergic receptor; beta3-Adrenoreceptor; Beta3-AR; FLJ99960
基因别名: ADRB; Adrb-3; ADRB3; ADRB3R; B3AR; B3bar; BETA3AR
UniProt ID: (Human) P13945, (Mouse) P25962, (Rat) P26255
Entrez Gene ID: (Human) 155, (Mouse) 11556, (Rat) 25645
beta-adrenergic receptor activity
protein binding
beta3-adrenergic receptor activity
beta-3 adrenergic receptor binding
protein homodimerization activity
epinephrine binding
norepinephrine binding
signal transducer activity
G-protein coupled receptor activity
adrenergic receptor activity
G-protein coupled receptor
temperature homeostasis
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
carbohydrate metabolic process
generation of precursor metabolites and energy
energy reserve metabolic process
receptor-mediated endocytosis
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
cell-cell signaling
aging
response to cold
heat generation
negative regulation of multicellular organism growth
eating behavior
positive regulation of MAPK cascade
response to antibiotic
brown fat cell differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adrenergic receptor signaling pathway
