Invitrogen

c-Met Polyclonal Antibody

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c-Met Antibody (PA5-117533) in WB

Western Blot analysis of c-Met using c-Met Polyclonal Antibody (Product # PA5-117533) at 2 µg/mL. Positive WB detected in Recombinant protein. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 42 kDa. Observed band size: 52 kDa

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产品信息

PA5-117533

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:5,000

产品规格

种属反应

Zebrafish

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Zebrafish MET proto-oncogene, receptor tyrosine kinase protein (76-179aa)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.014 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.03% ProClin 300

保存条件

-20°C or -80°C if preferred

运输条件

Wet ice

AB_2902162

产品详细信息

This antibody has been tested in direct-ELISA

靶标信息

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

仅用于科研。不用于诊断过程。未经明确授权不得转售。