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产品信息
A301-686A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 1 and 50 of human calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat
靶标信息
EEF2K is a highly conserved Serine/Threoning kinase in the calmodulin signaling pathway whose activity is increased in cancers including breast cancer. EEF2K (eukaryotic elongation factor 2 kinase) is a threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Up activation, by a variety of upstream kinases including AMPK or TRPM7, EEF2K phosphorylates the elongation factor EEF2 at a single site. Then, EEF2K renders EEF2 unable to bind ribosomes and inactive - in turn, the rate of protein synthesis is reduced.
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生物信息学
蛋白别名: Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; EC 2.7.11.20; eEF-2 kinase; EF2K; elongation factor-2 kinase; euk; eukaroytic elongation factor 2 kinase; Eukaryotic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; kinase eEF2K
基因别名: eEF-2K; EEF2K; HSU93850
UniProt ID: (Human) O00418
Entrez Gene ID: (Human) 29904
response to ischemia
translational elongation
regulation of protein autophosphorylation
cellular response to insulin stimulus
negative regulation of apoptotic process
positive regulation of endocytosis
protein autophosphorylation
positive regulation of synapse assembly
positive regulation of dendritic spine morphogenesis
cellular response to calcium ion
cellular response to cAMP
cellular response to anoxia
cellular response to brain-derived neurotrophic factor stimulus
response to prolactin
