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产品信息
PA5-116997
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human EIF4E2 (NP_0048371)
偶联物
形式
Liquid
浓度
0.45 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901627
产品详细信息
Positive Samples: BT-474, HL-60, Mouse kidney
Immunogen sequence: MNNKFDALKD DDSGDHDQNE ENSTQKDGEK EKTERDKNQS SSKRKAVVPG PAEHPLQYNY TFWYSRRTPG RPTSSQSYEQ NIKQIGTFAS VEQFWRFYSH MVRPGDLTGH SDFHLFKEGI KPMWEDDANK NGGKWIIRLR KGLASRCWEN LILAMLGEQF MVGEEICGAV VSVRFQEDII SIWNKTASDQ ATTARIRDTL RRVLNLPPNT IMEYKTHTDS IKMPGRLGPQ RLLFQNLWKP
靶标信息
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: eIF-4E type 2; eIF4E type 2; eIF4E-2; eIF4E-like cap-binding protein; eIF4E-like protein 4E-LP; eukar; Eukaryotic translation initiation factor 4E homologous protein; eukaryotic translation initiation factor 4E like 3; eukaryotic translation initiation factor 4E member 2; Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation factor 4E-like 3; h4EHP; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 2; mRNA cap-binding protein type 3
基因别名: 2700069E09Rik; 4E-LP; 4EHP; AI036339; AV129531; D0H0S6743E; EIF4E2; EIF4EL3; IF4e
UniProt ID: (Human) O60573, (Mouse) Q8BMB3
Entrez Gene ID: (Human) 9470, (Rat) 363275, (Mouse) 26987
