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mGluR1/mGluR5 Antibody (MA5-45550) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with mGluR1/5 monoclonal antibody (Product # MA5-45550) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1,000, 1:5,000 for... View More
产品信息
MA5-45550
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N75/33
抗原
Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932004
产品详细信息
1 µg/mL of MA5-45550 was sufficient for detection of mGluR1/5 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 130kDa (both mGluR1 and mGluR5).
This antibody was formerly sold as clone S75-33.
靶标信息
may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member E; glutamate receptor; glutamate receptor, metabotropic 1; glutamate receptor, metabotropic 5; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 1; Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; mGluR1; mGluR5; mGlurR1a; protein phosphatase 1, regulatory subunit 85; protein phosphatase 1, regulatory subunit 86
基因别名: 4930455H15Rik; 6430542K11Rik; AI850523; ENSMUSG00000075319; Glu5R; Gm10828; GPRC1A; GPRC1E; GRM1; GRM5; MGLU1; mGlu5; MGLUR1; MGLUR5; mGluR5b; nmf373; PPP1R85; PPP1R86; rcw; SCAR13; wobl
UniProt ID: (Human) Q14757, (Human) P41594, (Mouse) P97772, (Rat) P23385, (Rat) P31424, (Mouse) Q3UVX5
Entrez Gene ID: (Human) 2911, (Human) 2915, (Mouse) 14816, (Rat) 24414, (Rat) 24418, (Mouse) 108071
G-protein coupled receptor activity
protein binding
glutamate receptor activity
PLC activating G-protein coupled glutamate receptor activity
signal transducer activity
estrogen receptor binding
identical protein binding
calmodulin binding
PDZ domain binding
A2A adenosine receptor binding
G-protein coupled receptor
activation of MAPKK activity
activation of MAPK activity
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
locomotory behavior
sensory perception of pain
dimeric G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
regulation of sensory perception of pain
regulation of synaptic transmission, glutamatergic
cellular response to electrical stimulus
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
learning
regulation of long-term neuronal synaptic plasticity
cognition
signal transduction
calcium-mediated signaling
regulation of MAPK cascade
regulation of glutamate secretion
membrane depolarization
synaptic transmission, GABAergic
activation of MAPKKK activity
desensitization of G-protein coupled receptor protein signaling pathway
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of locomotion
phosphatidylinositol-mediated signaling
positive regulation of long-term neuronal synaptic plasticity
