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mGluR4 (extracellular) Antibody (AGC-014-200UL) in ICC/IF
Expression of mGluR4 in rat PC12 cells - Cell surface detection of mGluR4 in live intact rat PC12 pheochromocytoma cells. A. Extracellular staining of cells using Anti-mGluR4 (extracellular) Antibody (#AGC-014), (1:50), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Live view of the cells. C. Merge of A and B. Nuclei are stained with Hoechst 33342 (blue).
产品信息
AGC-014-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KPKGHPHMNSIR(C), corresponding to amino acid residues 33-44 of rat mGluR4, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G protein-coupled receptor GRM4; G protein-coupled receptor, family C, group 1, member D; glutamate receptor; glutamate receptor, metabotropic 4; Metabotropic glutamate receptor 4; mGluR4
基因别名: GPRC1D; GRM4; mGlu4; MGLUR4
UniProt ID: (Human) Q14833, (Rat) P31423, (Mouse) Q68EF4
Entrez Gene ID: (Human) 2914, (Rat) 24417, (Mouse) 268934
activation of MAPK activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
neurotransmitter secretion
positive regulation of MAPK cascade
regulation of neuron apoptotic process
regulation of synaptic transmission, glutamatergic
learning
negative regulation of cell proliferation
gamma-aminobutyric acid secretion
neuron projection development
synaptic transmission, glutamatergic
negative regulation of apoptotic process
negative regulation of synaptic transmission
synaptic transmission, GABAergic
signal transduction
G-protein coupled receptor signaling pathway
