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产品信息
PA5-32861
产品规格
种属反应
Bat,
Bovine,
Dog,
Chicken,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM5 / MGLUR5.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550322
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Bovine, Hamster, Horse, Rabbit, Pig, Turkey, Zebra finch, Chicken, Platypus, Lizard (100%); Xenopus (94%); Opossum, Pufferfish (88%); Zebrafish (82%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
靶标信息
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A830007B11Rik; D16Ium24; D16Ium24e; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; G-protein coupled receptor; Glur-5; Glur5; Glurbeta1; glutamate receptor; glutamate receptor, metabotropic 5; GPRC1A; GRM 1; GRM 5; GRM1; GRM1 alpha; GRM1A; metabotropic 1; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; MGC25101; mGlu1; mGluR; mGluR1; mGluR1 alpha; mGluR1A; mGluR5; mGluR5a; protein phosphatase 1, regulatory subunit 86
基因别名: 6430542K11Rik; AI850523; Glu5R; GPRC1E; GRM5; mGlu5; MGLUR5; mGluR5b; PPP1R86
UniProt ID: (Human) P41594, (Rat) P31424, (Mouse) Q3UVX5
Entrez Gene ID: (Horse) 100060364, (Human) 2915, (Dog) 485146, (Rabbit) 100340633, (Chicken) 373933, (Pig) 102161751, (Rat) 24418, (Mouse) 108071
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
learning
locomotory behavior
regulation of long-term neuronal synaptic plasticity
cognition
regulation of synaptic transmission, glutamatergic
activation of MAPKKK activity
desensitization of G-protein coupled receptor protein signaling pathway
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of locomotion
phosphatidylinositol-mediated signaling
positive regulation of long-term neuronal synaptic plasticity
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
signal transduction
G-protein coupled receptor signaling pathway
