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Product Details
AGC-007-F-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EGFAQENSKYNKTC, corresponding to amino acids 367-380 of rat mGluR5, Extracellular, N-terminus
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A830007B11Rik; D16Ium24; D16Ium24e; G protein coupled receptor, family C, group 1, member E; G protein-coupled receptor GRM5; G protein-coupled receptor, family C, group 1, member E; Glur-5; Glur5; Glurbeta1; glutamate receptor; glutamate receptor, metabotropic 5; GPRC1A; GRM 1; GRM 5; GRM1; GRM1 alpha; GRM1A; metabotropic 1; metabotropic glutamate receptor (mGluR5); Metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor subtype 5b; metabotropic glutamate receptor type 5; MGC25101; mGlu1; mGluR; mGluR1; mGluR1 alpha; mGluR1A; mGluR5; mGluR5a; protein phosphatase 1, regulatory subunit 86
Gene Aliases: 6430542K11Rik; AI850523; Glu5R; GPRC1E; GRM5; mGlu5; MGLUR5; mGluR5b; PPP1R86
UniProt ID: (Human) P41594, (Rat) P31424, (Mouse) Q3UVX5
Entrez Gene ID: (Human) 2915, (Rat) 24418, (Mouse) 108071
protein kinase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
learning
locomotory behavior
regulation of long-term neuronal synaptic plasticity
cognition
regulation of synaptic transmission, glutamatergic
activation of MAPKKK activity
desensitization of G-protein coupled receptor protein signaling pathway
regulation of transcription, DNA-templated
protein phosphorylation
negative regulation of locomotion
phosphatidylinositol-mediated signaling
positive regulation of long-term neuronal synaptic plasticity
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
signal transduction
G-protein coupled receptor signaling pathway
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