Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 4
mGluR7 (extracellular) Antibody (AGC-017-200UL) in ICC/IF
Expression of mGluR7 in rat PC12 cells - Cell surface detection of mGluR7 in live intact rat pheochromocytoma PC12 cells. A. Cells were stained with Anti-mGluR7 (extracellular) Antibody (#AGC-017), (1:100), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Live view of the cells. C. Merge of the two pictures.
产品信息
AGC-017-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TISGSKKEDTDRKC, corresponding to amino acid residues 377-390 of rat mGluR7, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: FLJ40498; G protein-coupled receptor GRM7; G protein-coupled receptor, family C, group 1, member G; glutamate receptor; glutamate receptor, metabotropic 7; Metabotropic glutamate receptor 7; metabotropic glutamate receptor mGluR7; metabotropic glutamate receptor subtype 7b; mGlu7a receptor; mGluR7; protein phosphatase 1, regulatory subunit 87
基因别名: 6330570A01Rik; BB176677; C030018L03; E130018M02Rik; GLUR7; Gpr1g; GPRC1G; GRM7; MGLU7; MGLUR7; PPP1R87
UniProt ID: (Human) Q14831, (Rat) P35400, (Mouse) Q68ED2
Entrez Gene ID: (Human) 2917, (Rat) 81672, (Mouse) 108073
group III metabotropic glutamate receptor activity
voltage-gated calcium channel activity
calcium channel regulator activity
glutamate receptor activity
adenylate cyclase inhibitor activity
serine binding
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
calcium ion binding
protein binding
calmodulin binding
glutamate binding
PDZ domain binding
protein homodimerization activity
calcium-dependent protein binding
signal transducer activity
G-protein coupled receptor activity
G-protein coupled receptor
conditioned taste aversion
behavioral fear response
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
sensory perception of sound
sensory perception of smell
short-term memory
negative regulation of glutamate secretion
transmission of nerve impulse
adult behavior
negative regulation of cAMP biosynthetic process
regulation of cyclase activity
regulation of synaptic transmission, glutamatergic
calcium ion transmembrane transport
negative regulation of adenylate cyclase activity
learning or memory
memory
associative learning
multicellular organismal response to stress
regulation of ion transmembrane transport
neurological system process
signal transduction
G-protein coupled receptor signaling pathway
response to stimulus
regulation of neuron death
