Osenses

mature NT3 Polyclonal Antibody

3 篇参考文献

查看其他20个NTF3抗体

产品信息

OSN00022W-100UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-1:2,000

-

免疫组化 (IHC)

1:300-1:2,000

-

其他PubMed (Misc)

-

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from aa region 140-200 of human NT3 conjugated to an immunogenic carrier protein was used as the antigen

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in many other species including rat and mouse.

Specificity of this antibody: mature NT-3.

靶标信息

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Primary structure and biological activity of a novel human neurotrophic factor.

Neuron

Rosenthal A,Goeddel DV,Nguyen T,Lewis M,Shih A,Laramee GR,Nikolics K,Winslow JW

Tue May 01 00:00:00 UTC 1990

Molecular cloning of a human gene that is a member of the nerve growth factor family.

Proceedings of the National Academy of Sciences of the United States of America

Jones KR,Reichardt LF

Mon Oct 01 00:00:00 UTC 1990

Cloning and expression of a cDNA encoding a novel human neurotrophic factor.

FEBS letters

Kaisho Y,Yoshimura K,Nakahama K

Mon Jun 18 00:00:00 UTC 1990

生物信息学

蛋白别名: HDNF; Nerve growth factor 2; Neurotrophic factor; Neurotrophin-3; neurotrophin-3 (HDNF/NT-3); NGF-2; NT-3

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基因别名: AI316846; AI835689; HDNF; NGF-2; NGF2; NT-3; NT3; Ntf-3; NTF3

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UniProt ID: (Human) P20783, (Mouse) P20181, (Rat) P18280

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Entrez Gene ID: (Human) 4908, (Mouse) 18205, (Rat) 81737

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receptor binding neurotrophin p75 receptor binding protein binding growth factor activity chemoattractant activity nerve growth factor binding neurotrophin receptor binding neurotrophic factor

activation of MAPK activity positive regulation of receptor internalization signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell-cell signaling nervous system development positive regulation of cell proliferation positive regulation of cell migration activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation myelination regulation of apoptotic process negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of glial cell differentiation neuron projection morphogenesis positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation modulation of synaptic transmission positive chemotaxis induction of positive chemotaxis activation of GTPase activity positive regulation of actin cytoskeleton reorganization neuromuscular synaptic transmission glial cell fate determination axon guidance brain development peripheral nervous system development epidermis development nerve development mechanoreceptor differentiation regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter enteric nervous system development neuron development generation of neurons smooth muscle cell differentiation