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p53 (R175H Mutant) Antibody (MA5-46935) in ICC/IF
Immunofluorescent analysis of p53 (R175H Mutant) in mock and transfected 293T cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: p53 (R175H Mutant) stained by p53 (R175H Mutant) monoclonal antibody (Product # MA5-46935) diluted at 1:1900. Blue: Fluoroshield with DAPI.
产品信息
MA5-46935
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1129
抗原
Carrier-protein conjugated synthetic peptide surrounding mutant R175H of human p53. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938007
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains|The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism|Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome|Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms|Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277)
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCC7; BMFS5; casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; LFS1; p45; P53; TRP53; tumor protein p53
基因别名: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PRO2975
UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752
Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011
endopeptidase activity
cysteine-type endopeptidase activity
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity involved in apoptotic process
protein kinase activity
protein serine/threonine kinase activity
ATP binding
kinase activity
protease
non-receptor serine/threonine protein kinase
response to hypoxia
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
regulation of autophagy
protein processing
response to lipopolysaccharide
interleukin-1 beta production
response to ATP
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
mitochondrial depolarization
membrane hyperpolarization
pyroptosis
cellular response to mechanical stimulus
cellular response to organic substance
programmed necrotic cell death
toxin transport
protein phosphorylation
phagocytosis
Golgi organization
mitotic nuclear division
cell surface receptor signaling pathway
regulation of cell shape
Wnt signaling pathway
peptidyl-serine phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
intermediate filament cytoskeleton organization
cell division
negative regulation of canonical Wnt signaling pathway
regulation of GTP binding
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
cell morphogenesis
