Invitrogen

p73 Polyclonal Antibody

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p73 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

p73 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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p73 Antibody (PA5-86461) in IHC (P)

Immunohistochemical analysis of p73 in paraffin-embedded human breast carcinoma tissue. Sample was incubated with p73 polyclonal antibody (Product # PA5-86461) using a 1:50 dilution.

p73 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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p73 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of p73 in paraffin-embedded human breast carcinoma tissue. Sample was incubated with p73 polyclonal antibody (Product # PA5-86461) using a 1:50 dilution.

产品信息

PA5-86461

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide, corresponding to amino acids 271-320 of Human p73.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2803239

产品详细信息

Purity is > 95% by SDS-PAGE.

靶标信息

P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; RP23-254N4.10; transformation related protein 73; Tumor protein p73

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基因别名: deltaNp73; P73; TAp73; TP73; Trp73

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UniProt ID: (Human) O15350, (Mouse) Q9JJP2

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Entrez Gene ID: (Human) 7161, (Rat) 362675, (Mouse) 22062

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RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding p53 binding chromatin binding damaged DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein kinase binding identical protein binding transcription regulatory region DNA binding metal ion binding DNA binding double-stranded DNA binding sequence-specific DNA binding P53-like transcription factor

negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity kidney development mismatch repair transcription from RNA polymerase II promoter cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle arrest regulation of mitotic cell cycle intrinsic apoptotic signaling pathway in response to DNA damage response to X-ray response to organonitrogen compound response to gamma radiation regulation of gene expression viral process mitotic G1 DNA damage checkpoint cellular response to UV response to drug intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process negative regulation of JUN kinase activity negative regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of oligodendrocyte differentiation protein tetramerization negative regulation of cardiac muscle cell proliferation positive regulation of cell cycle arrest positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator release of cytochrome c from mitochondria inflammatory response post-embryonic development hippocampus development forebrain development cerebrospinal fluid secretion positive regulation of apoptotic process regulation of neuron apoptotic process positive regulation of cell size digestive tract morphogenesis neuron development positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process cell cycle