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产品信息
MA5-16183
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
38C674.2
抗原
Synthetic peptide (LYVGDPARHLAT) of p73 (deltaNp73) protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2537702
靶标信息
p73 was identified as a long-lost cousin of tumor suppressor protein, p53 (4). p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (3). The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (2). Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein (1) It was found p73 to be upregulated in a significant fraction of anaplastic thyroid cancers, whereas it was not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer.
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生物信息学
蛋白别名: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; RP23-254N4.10; transformation related protein 73; Tumor protein p73
基因别名: deltaNp73; P73; TAp73; TP73; Trp73
UniProt ID: (Human) O15350, (Mouse) Q9JJP2
Entrez Gene ID: (Human) 7161, (Rat) 362675, (Mouse) 22062
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
p53 binding
chromatin binding
damaged DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
identical protein binding
transcription regulatory region DNA binding
metal ion binding
DNA binding
double-stranded DNA binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
release of cytochrome c from mitochondria
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
inflammatory response
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle
cell cycle arrest
regulation of mitotic cell cycle
post-embryonic development
response to X-ray
response to gamma radiation
regulation of gene expression
hippocampus development
forebrain development
mitotic G1 DNA damage checkpoint
cerebrospinal fluid secretion
cellular response to UV
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of apoptotic process
negative regulation of JUN kinase activity
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
negative regulation of neuron differentiation
positive regulation of cell size
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract morphogenesis
neuron development
positive regulation of oligodendrocyte differentiation
protein tetramerization
negative regulation of cardiac muscle cell proliferation
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of apoptotic signaling pathway
kidney development
mismatch repair
intrinsic apoptotic signaling pathway in response to DNA damage
response to organonitrogen compound
viral process
response to drug
regulation of apoptotic process
positive regulation of cell cycle arrest
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
