Alomone Labs, LTD

proGDNF Polyclonal Antibody

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proGDNF Antibody (ANT-026-200UL) in WB

Western blot analysis of human GDNF pro-domain fusion protein at 40 ng (lanes 1 and 4), 30 ng (lanes 2 and 5) and 20 ng (lanes 3 and 6): - 1-3. Anti-proGDNF Antibody (#ANT-026), (1:200).4-6. Anti-proGDNF Antibody , preincubated with proGDNF Blocking Peptide (#BLP-NT026).Note that the expected MW of the GDNF pro-domain fusion protein is 21 kD.

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产品信息

ANT-026-200UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)PEDYPDQFDDVMD, corresponding to amino acid residues 54-66 of human GDNF (precursor), Pro-domain of the GDNF protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinsons disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Astrocyte-derived trophic factor; ATF; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; Glial cell line-derived neurotrophic factor; hGDNF; mGDNF; neurotrophic factor

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基因别名: AI385739; ATF1; ATF2; GDNF; gndf; HFB1-GDNF; HSCR3

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UniProt ID: (Human) P39905, (Mouse) P48540, (Rat) Q07731

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Entrez Gene ID: (Human) 2668, (Mouse) 14573, (Rat) 25453

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功能

Ras guanyl-nucleotide exchange factor activity receptor binding protein binding growth factor activity protein homodimerization activity transforming growth factor beta receptor binding glial cell-derived neurotrophic factor receptor binding neurotrophic factor

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