NeoBiotechnologies

von Willebrand Factor/Factor VIII Related-Ag (Endothelial Marker) Recombinant Rabbit Monoclonal Antibody (VWF/4384R)

von Willebrand Factor/Factor VIII Related-Ag (Endothelial Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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von Willebrand Factor/Factor VIII Related-Ag (Endothelial Marker) Antibody (7450-RBM17-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human bone marrow stained with vWF Recombinant Rabbit Monoclonal Antibody (VWF/4384R).

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产品信息

7450-RBM17-P1

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

VWF/4384R

抗原

Recombinant fragment (around aa 1150-1250) of human vWFprotein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Antibody is stable for 24 months.

Positive Control: HUVEC cells. Human tonsil. Cellular Localization: Cytoplasm.

Specificity Comments: Human von Willebrand factor (VWFor factor VIII-related antigen) is a 309 kDa multimeric plasma glycoprotein, important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Von Willebrand factor also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand factor is synthesized by endothelial cells and is reported to be expressed in a number of tumors of vascular origin. IHC results aid in the classification of acute myeloid leukemia FAB type M7, angiosarcoma and epithelioid hemangioendothelioma.

靶标信息

Von Willebrand factor (vWf) is a series of self-aggregated structures, all derived from common glycoprotein subunits, synthesized in endothelial cells and megakaryocytes. The molecular mass of the monomeric vWf unit is 225 kDa. vWf binds to circulating factor VIIIc (antihemophilic factor), hereby stabilizing the latter thus being an important factor in the normal primary haemostasis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。