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NeoBiotechnologies
ALK (Anaplastic Lymphoma Kinase)/CD246 Recombinant Rabbit Monoclonal Antibody (ALK1/7008R)
产品信息
238-RBM10-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ALK1/7008R
抗原
Recombinant human ALK protein fragment corresponding to the cytoplasmic domain. The antigen corresponds to amino acid range 1058-1620 of the target protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Antibody is stable for 24 months.
Positive Control: Human Anaplastic Large Cell Lymphoma (ALCL) tissue. Cellular Localization: Cytoplasm. Nuclear.
Specificity Comments: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase of the insulin receptor superfamily. ALK is typically expressed at low levels in regions of the developing central and peripheral nervous system.ALK may be activated in cancer through multiple mechanisms. The most common mechanism is through formation of a fusion protein from chromosomal translocations, as in the case of anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumors. ALK may also be amplified through mutation, as in neuroblastomas. Various solid tumors, such as non-small cell lung carcinoma (NSCLC) and brain cancers were also found to aberrantly express ALK. ALK staining is present within both the nucleus and cytoplasm, and are positive in about 60% of ALCL. ALK protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome.
靶标信息
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; npm-alk; p80; TFG/ALK
基因别名: ALK; CD246; NBLST3
UniProt ID: (Human) Q9UM73
Entrez Gene ID: (Human) 238
activation of MAPK activity
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell proliferation
phosphorylation
peptidyl-tyrosine phosphorylation
NIK/NF-kappaB signaling
regulation of apoptotic process
protein autophosphorylation
neuron development
positive regulation of NF-kappaB transcription factor activity
