NeoBiotechnologies

AMACR/p504S (Prostate Cancer Marker) Recombinant Rabbit Monoclonal Antibody (13H4)

AMACR/p504S (Prostate Cancer Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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AMACR/p504S (Prostate Cancer Marker) Antibody (23600-RBM1-P1) in IHC (P)

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with AMACR/p504S (Prostate Cancer Marker) Recombinant Monoclonal Antibody (Product # 23600-RBM1-P1).

AMACR/p504S (Prostate Cancer Marker) Antibody in Western Blot (WB)

AMACR/p504S (Prostate Cancer Marker) Antibody in SDS-PAGE (SDS-PAGE)

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产品信息

23600-RBM1-P1

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

肽阵列 (Array)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

13H4

抗原

Recombinant full-length human AMACR protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Antibody is stable for 24 months.

Positive Control: HEK cells. Human kidney or prostate adeno carcinoma. Cellular Localization: Cytoplasm

Specificity Comments: This antibody recognizes a protein of 54kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and -oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adeno carcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.

靶标信息

P504S/AMACR/a-Methylacyl-CoA Racemase is an essential enzyme in the b-oxidation of branched-chain fatty acids. High expression of P504S protein is found in prostatic adenocarcinoma but not in benign prostate tissue by immunohistochemical staining in paraffin-embedded tissue. The expression of P504S is also detected in two premalignant lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia.

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