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产品信息
PA5-36922
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to residues in human AOX1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553817
产品详细信息
This antibody detects endogenous protein at a molecular weight of 148 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes the oxidation of a variety of aldehydes, leading to the production of hydrogen peroxide. Under certain conditions, AOX1 can catalyze the formation of the superoxide free radical. Defects in oxygen radical metabolism have been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), an autosomal dominant neurodegenerative disorder characterized by the death of motor neurons in the spinal cord, brain and brainstem. Significantly, AOX1 is highly expressed in the ventral horn of the spinal cord and the gene that encodes AOX1 is located in a chromosomal region that is frequently found to be implicated in ALS2. This evidence suggests that AOX1 is a candidate gene for ALS2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aldehyde oxidase; aldehyde oxidase (female form); Aldehyde oxidase 1; aldehyde oxidase 2; Azaheterocycle hydroxylase; Azaheterocycle hydroxylase 1; Retinal oxidase
基因别名: AI196512; AI255253; AO; AOH1; Aox-1; Aox-2; AOX1; Aox2; Moro; Ro
UniProt ID: (Human) Q06278, (Mouse) O54754, (Rat) Q9Z0U5
Entrez Gene ID: (Human) 316, (Mouse) 11761, (Rat) 54349
aldehyde oxidase activity
xanthine dehydrogenase activity
iron ion binding
electron carrier activity
oxidoreductase activity, acting on CH-OH group of donors
molybdopterin cofactor binding
flavin adenine dinucleotide binding
NAD binding
2 iron, 2 sulfur cluster binding
catalytic activity
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity
metal ion binding
iron-sulfur cluster binding
