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产品信息
PA5-33339
产品规格
种属反应
Human,
Non-human primate
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 13 amino acid peptide from internal region of human AGT / Angiotensinogen.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550721
产品详细信息
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey (100%) Marmoset (85%).
靶标信息
The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8
基因别名: AGT; ANHU; SERPINA8
UniProt ID: (Human) P01019
Entrez Gene ID: (Human) 183
regulation of cell growth
positive regulation of cytokine production
kidney development
blood vessel remodeling
angiotensin maturation
regulation of blood volume by renin-angiotensin
renin-angiotensin regulation of aldosterone production
regulation of renal output by angiotensin
regulation of heart rate
regulation of blood vessel size by renin-angiotensin
renal system process
angiotensin-mediated drinking behavior
positive regulation of extracellular matrix constituent secretion
cellular sodium ion homeostasis
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
phospholipase C-activating G-protein coupled receptor signaling pathway
activation of phospholipase C activity
nitric oxide mediated signal transduction
cell-cell signaling
female pregnancy
aging
regulation of blood pressure
positive regulation of activation of JAK2 kinase activity
positive regulation of endothelial cell migration
positive regulation of cardiac muscle hypertrophy
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol esterification
negative regulation of endopeptidase activity
regulation of norepinephrine secretion
positive regulation of phosphatidylinositol 3-kinase signaling
artery smooth muscle contraction
response to muscle activity involved in regulation of muscle adaptation
negative regulation of angiogenesis
regulation of vasoconstriction
negative regulation of cell growth
positive regulation of cellular protein metabolic process
positive regulation of superoxide anion generation
positive regulation of NAD(P)H oxidase activity
negative regulation of tissue remodeling
low-density lipoprotein particle remodeling
catenin import into nucleus
regulation of renal sodium excretion
positive regulation of renal sodium excretion
regulation of cell proliferation
vasodilation
positive regulation of nitric oxide biosynthetic process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of blood pressure
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
fibroblast proliferation
positive regulation of fibroblast proliferation
regulation of long-term neuronal synaptic plasticity
smooth muscle cell proliferation
cytokine secretion
positive regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of NF-kappaB transcription factor activity
negative regulation of neurotrophin TRK receptor signaling pathway
stress-activated MAPK cascade
regulation of calcium ion transport
regulation of transmission of nerve impulse
cell growth involved in cardiac muscle cell development
positive regulation of protein tyrosine kinase activity
ERK1 and ERK2 cascade
uterine smooth muscle contraction
cellular response to mechanical stimulus
positive regulation of branching involved in ureteric bud morphogenesis
regulation of extracellular matrix assembly
positive regulation of gap junction assembly
regulation of cardiac conduction
positive regulation of reactive oxygen species metabolic process
positive regulation of extrinsic apoptotic signaling pathway
