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产品信息
PA5-20269
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 14 amino acid peptide from near the amino terminus of human Bfl-1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11156205
产品详细信息
Despite the predicted molecular weight, Bfl-1 often migrates at a higher molecular weight in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is mouse kidney tissue lysate.
PA5-20269 can be used with blocking peptide PEP-0384.
靶标信息
Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: A1-A; B-cell leukemia/lymphoma 2 related protein A1; B-cell leukemia/lymphoma 2 related protein A1a; B-cell leukemia/lymphoma 2 related protein A1d; Bcl-2-like protein 5; Bcl-2-related protein A1; Bcl2-L-5; BCL2-related protein A1; BCL2-related protein A1d; GRS protein; hematopoietic BCL2-related protein A1; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
基因别名: A1; ACC-1; ACC-2; ACC1; ACC2; BB218357; BCL2A1; Bcl2a1a; Bcl2a1d; BCL2L5; Bfl-1; BFL1; GRS; HBPA1
UniProt ID: (Human) Q16548, (Mouse) Q07440
Entrez Gene ID: (Human) 597, (Rat) 170929, (Mouse) 12044
release of cytochrome c from mitochondria
mitochondrial fusion
intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of apoptotic process
negative regulation of apoptotic process
transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
apoptotic process
T cell differentiation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
T cell receptor signaling pathway
B cell homeostasis
negative regulation of B cell apoptotic process
regulation of apoptotic process
negative regulation of intrinsic apoptotic signaling pathway
