Invitrogen

BMP-7 Polyclonal Antibody

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产品信息

PA5-34602

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1 µg/mL
-

免疫组化（石蜡） (IHC (P))

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide conjugated to KLH derived from within residues 300 - 400 of Human BMP7.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.9 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2551954

产品详细信息

For Western Blot, this antibody has non-specific bands at 10 kDa,33 kDa and 38 kDa.

Heat mediated antigen retrieval recommended prior to tissue staining.

This antibody is predicted to react with rabbit, horse, chicken and pig based on sequence homology.

靶标信息

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BMP; BMP-7; bone moorphogenic protein-7; Bone morphogenetic protein; Bone morphogenetic protein 7; OP-1; Osteogenic protein 1; RP11-560A15.5

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基因别名: BMP-7; BMP7; OP-1; OP1

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UniProt ID: (Human) P18075, (Mouse) P23359

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Entrez Gene ID: (Human) 655, (Mouse) 12162, (Rat) 85272

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功能
cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity heparin binding BMP receptor binding growth factor
参与通路
skeletal system development ossification metanephros development ureteric bud development mesoderm formation mesonephros development epithelial to mesenchymal transition axon guidance embryonic pattern specification negative regulation of striated muscle cell apoptotic process positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation dendrite development embryonic limb morphogenesis positive regulation of bone mineralization BMP signaling pathway epithelial cell differentiation negative regulation of NF-kappaB transcription factor activity response to estradiol response to vitamin D positive regulation of heterotypic cell-cell adhesion protein localization to nucleus growth negative regulation of phosphorylation negative regulation of NF-kappaB import into nucleus odontogenesis of dentin-containing tooth regulation of apoptotic process positive regulation of apoptotic process steroid hormone mediated signaling pathway negative regulation of MAP kinase activity response to peptide hormone negative regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of Notch signaling pathway negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube mesenchymal cell differentiation neuron projection morphogenesis cartilage development embryonic skeletal joint morphogenesis regulation of pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction branching involved in salivary gland morphogenesis mesenchyme development negative regulation of cell death negative regulation of prostatic bud formation regulation of branching involved in prostate gland morphogenesis monocyte aggregation cellular response to hypoxia cellular response to BMP stimulus negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis negative regulation of glomerular mesangial cell proliferation metanephric mesenchyme morphogenesis nephrogenic mesenchyme morphogenesis metanephric mesenchymal cell proliferation involved in metanephros development positive regulation of dendrite development positive regulation of hyaluranon cable assembly regulation of removal of superoxide radicals eye development kidney development multicellular organism development pattern specification process salivary gland morphogenesis negative regulation of cell proliferation organ morphogenesis positive regulation of cell death cell differentiation tube morphogenesis regulation of phosphorylation regulation of MAPK cascade positive regulation of cell differentiation positive regulation of neuron differentiation cell development camera-type eye morphogenesis anatomical structure formation involved in morphogenesis negative regulation of neurogenesis
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