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产品信息
PA5-78949
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human CCR5 (19-34aa PCQKINVKQIAARLLP).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746065
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CCR-5; CD195; CD195 antigen; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; chemokine receptor CCR5; CHEMR13; HIV-1 fusion coreceptor; MIP-1 alpha receptor
基因别名: AM4-7; CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; CKR-5; CKR5; CMKBR5; IDDM22
UniProt ID: (Human) P51681, (Mouse) P51682
Entrez Gene ID: (Human) 1234, (Mouse) 12774
virus receptor activity
actin binding
phosphatidylinositol phospholipase C activity
chemokine receptor activity
protein binding
coreceptor activity
C-C chemokine receptor activity
C-C chemokine binding
chemokine (C-C motif) ligand 5 binding
glycoprotein binding
signal transducer activity
G-protein coupled receptor activity
protein kinase binding
MAPK cascade
dendritic cell chemotaxis
calcium ion transport
chemotaxis
inflammatory response
immune response
cellular defense response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
fusion of virus membrane with host plasma membrane
calcium-mediated signaling
signaling
entry into host cell
chemokine-mediated signaling pathway
response to cholesterol
cellular response to lipopolysaccharide
defense response
signal transduction
positive regulation of gene expression
positive regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of axon extension
positive regulation of fever generation
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of neuron differentiation
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
positive regulation of apoptotic process by virus
neuron death
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of macrophage apoptotic process
negative regulation of neural precursor cell proliferation
