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Description: This 9E8 monoclonal antibody reacts with human CD367, also known as dendritic cell immunoreceptor (DCIR) or Clec4A. This C-type lectin is expressed on monocytes, granulocytes, B cells, and plasmacytoid dendritic cells in peripheral blood. DCIR is also expressed on mature and immature monocyte-derived dendritic cells in vitro. DCIR is not expressed on NK or T cells. With its cytoplasmic ITIM domain, DCIR is an inhibitory receptor that recruits the SHP-1 and SHP-2 phosphatases upon ligand binding. Studies have demonstrated that DCIR plays a role in the interaction between dendritic cells and HIV-1.
Applications Reported: This 9E8 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This 9E8 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.
Filtration: 0.2 µm post-manufacturing filtered.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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蛋白别名: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; C-type lectin DDB27; C-type lectin domain family 4 member A; C-type lectin domain family 4, member A; C-type lectin superfamily member 6; CD367; Dendritic cell immunoreceptor; Lectin-like immunoreceptor
基因别名: CD367; CLEC4A; CLECSF6; DCIR; DDB27; HDCGC13P; LLIR
UniProt ID: (Human) Q9UMR7
Entrez Gene ID: (Human) 50856