Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
CD367 (Clec4A, DCIR) Antibody (12-9875-42) in Flow
Staining of normal human peripheral blood cells with Anti-Human CD19 APC (Product # 17-0199-42) and 0.25 µg of Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (left) or 0.25 µg of Anti-Human CD367 (Clec4A, DCIR) PE (right). Cells in the lymphocyte gate were used for analysis.
产品信息
12-9875-42
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
9E8
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
5 µL/Test
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2572756
产品详细信息
Description: This 9E8 monoclonal antibody reacts with human CD367, also known as dendritic cell immunoreceptor (DCIR) or Clec4A. This C-type lectin is expressed on monocytes, granulocytes, B cells, and plasmacytoid dendritic cells in peripheral blood. DCIR is also expressed on mature and immature monocyte-derived dendritic cells in vitro. DCIR is not expressed on NK or T cells. With its cytoplasmic ITIM domain, DCIR is an inhibitory receptor that recruits the SHP-1 and SHP-2 phosphatases upon ligand binding. Studies have demonstrated that DCIR plays a role in the interaction between dendritic cells and HIV-1.
Applications Reported: This 9E8 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This 9E8 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
生物信息学
蛋白别名: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; C-type lectin DDB27; C-type lectin domain family 4 member A; C-type lectin domain family 4, member A; C-type lectin superfamily member 6; CD367; Dendritic cell immunoreceptor; Lectin-like immunoreceptor
基因别名: CD367; CLEC4A; CLECSF6; DCIR; DDB27; HDCGC13P; LLIR
UniProt ID: (Human) Q9UMR7
Entrez Gene ID: (Human) 50856
