NeoBiotechnologies

CD50/ICAM3 Recombinant Rabbit Monoclonal Antibody (ICAM3, 2873R)

CD50/ICAM3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD50/ICAM3 Antibody (3385-RBM6-P1ABX) in IHC (P)

Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human tonsil using CD50, ICAM3 Recombinant Monoclonal Antibody (Product # 3385-RBM6-P1ABX).

CD50/ICAM3 Antibody in SDS-PAGE (SDS-PAGE)

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产品信息

3385-RBM6-P1ABX

应用

建议稀释比

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免疫组化（石蜡） (IHC (P))

1-2 µg/mL

抑制试剂 (IA)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

ICAM3, 2873R

抗原

Recombinant full-length human ICAM3 protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

靶标信息

CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。