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CDKN2C Antibody (PA5-99462) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded CDKN2C in human Breast cancer tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with CDKN2C polyclonal antibody (Product # PA5-99462) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-99462
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CDKN2C(Accession P42773), corresponding to amino acid residues L122-Q168.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818395
产品详细信息
Antibody detects endogenous levels of total p18 INK4c.
靶标信息
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CDK6 inhibitor p18; cyclin-dependent inhibitor; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18-INK4c; p18-INK6
基因别名: C77269; CDKN2C; CDKN6; INK4C; p18; p18-INK4C; p18-INK6; p18INK4c
UniProt ID: (Human) P42773, (Mouse) Q60772
Entrez Gene ID: (Human) 1031, (Rat) 54238, (Mouse) 12580
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
cell cycle arrest
negative regulation of cell proliferation
phosphorylation
negative regulation of cell growth
negative regulation of phosphorylation
oligodendrocyte differentiation
negative regulation of protein serine/threonine kinase activity
cell cycle
