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CNGA4 Antibody (PA5-114327) in ICC/IF
Immunocytochemical analysis of CNGA4 in SHSY5Y cells using a CNGA4 polyclonal antibody (Product #PA5-114327). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with the primary antibody for 1 hour at room temperature, washed with PBS. Alexa Fluor®488 Goat anti-Rabbit IgG was used as the secondary antibody at 1:100 dilution. The nuclear counter stain is DAPI.
产品信息
PA5-114327
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within rat CNGA4 aa 1-50
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2890435
靶标信息
Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CNCalpha4, CNG5; cng channel; CNG channel alpha-4; CNG-4; CNG4; cyclic nucleotide gated cation channel; cyclic nucleotide gated channel beta 2; cyclic nucleotide-gated cation channel alpha 4; cyclic nucleotide-gated cation channel alpha-4; Cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated olfactory channel subunit OCNC2; OCNC2; olfactory cyclic nucleotide-gated channel; Olfactory cyclic nucleotide-gated channel subunit 2
基因别名: Cgn2; CNCA2; CNG-4; CNG4; CNG5; CNGA4; CNGB2; OCNC2; OCNCb; OCNCBETA; rOCNC2
UniProt ID: (Human) Q8IV77, (Mouse) Q3UW12, (Rat) Q64359
Entrez Gene ID: (Human) 1262, (Mouse) 233649, (Rat) 85258
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
cAMP binding
cGMP binding
nucleotide binding
ion channel activity
intracellular cyclic nucleotide activated cation channel activity
ligand-gated ion channel
sensory perception of smell
regulation of membrane potential
response to stimulus
protein heterotetramerization
potassium ion transmembrane transport
transport
ion transport
ion transmembrane transport
regulation of ion transmembrane transport
transmembrane transport
cation transmembrane transport
phototransduction, visible light
