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CRF2/CRHR2 (extracellular) Antibody (ACR-052-200UL) in WB
Western blot analysis of mouse brain membrane (lanes 1 and 5), rat cerebellum (lanes 2 and 6), rat lung (lanes 3 and 7) and rat kidney (lanes 4 and 8) lysates: - 1-4. Anti-CRF2/CRHR2 (extracellular) Antibody (#ACR-052), (1:200).5-8. Anti-CRF2/CRHR2 (extracellular) Antibody , preincubated with CRF2/CRHR2 (extracellular) Blocking Peptide (#BLP-CR052).
产品信息
ACR-052-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EELLLDGWGEPPDPE, corresponding to amino acid residues 20-34 of rat CRHR2, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Corticotropin-releasing hormone (CRH; 122560) is a 41-amino acid peptide synthesized in the hypothalamus, and play a role in the neuroregulation, responses to stress and immune challenge. Corticotropin Releasing Factor Receptor 2 (CRHR2) was the receptor of CRH. The sepression of CRHR2 has been reported in various regions of the brain as well as in placenta, umbilical vein, heart, epididymis, gastrointestinal tract, adrenal and skeletal muscle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: corticotrophin releasing hormone receptor 2; corticotropin releasing factor receptor type 2 beta; corticotropin-releasing factor 2; Corticotropin-releasing factor receptor 2; corticotropin-releasing factor receptor subtype 2; Corticotropin-releasing hormone receptor 2; CRF 2 receptor; CRF-R 2; CRF-R-2; CRF-R2; CRF-RB; CRF2; CRF2 receptor, beta isoform; CRFR-2; CRH receptor 2 variant B; CRH-R 2; CRH-R-2; CRH-R2; Crh2 receptor
基因别名: CRF-R2; CRF-RB; CRF2; CRF2R; CRFR2; CRFR2alpha; CRFR2beta; CRH2R; CRHR2; HM-CRF
UniProt ID: (Human) Q13324, (Rat) P47866, (Mouse) Q60748
Entrez Gene ID: (Human) 1395, (Rat) 64680, (Mouse) 12922
actin filament organization
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
hormone-mediated signaling pathway
positive regulation of heart rate
positive regulation of gene expression
negative regulation of gene expression
negative regulation of norepinephrine secretion
positive regulation of serotonin secretion
sensory perception of pain
cerebellum development
hypothalamus development
negative regulation of cAMP biosynthetic process
positive regulation of cAMP biosynthetic process
epithelial cell differentiation
positive regulation of interleukin-6 production
negative regulation of epinephrine secretion
positive regulation of stress-activated MAPK cascade
negative regulation of luteinizing hormone secretion
gastric motility
catecholamine biosynthetic process
positive regulation of blood pressure
negative regulation of follicle-stimulating hormone secretion
skeletal muscle tissue growth
positive regulation of NF-kappaB transcription factor activity
long-term synaptic potentiation
negative regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of ERK1 and ERK2 cascade
cellular response to corticotropin-releasing hormone stimulus
cellular response to glucocorticoid stimulus
negative regulation of calcium ion import
negative regulation of feeding behavior
negative regulation of defecation
G-protein coupled receptor signaling pathway
feeding behavior
negative regulation of angiogenesis
positive regulation of cAMP metabolic process
positive regulation of cAMP-mediated signaling
negative regulation of cAMP-mediated signaling
signal transduction
