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产品信息
H00004051-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
4E11
抗原
CYP4F3 (NP_000887, 100 a.a. approximately 198 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: RIFHPTYIKP VLFAPAAIVP KDKVFYSFLK PWLGDGLLLS AGEKWSRHRR MLTPAFHFNI LKPYMKIFNE SVNIMHAKWQ LLASEGSARL DMFEHISLM
靶标信息
Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60 kDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Its role has been implicated in cell proliferation, vascular tone and natriuresis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; CYPIVF3; cytochrome P-450; Cytochrome P450 4F3; cytochrome P450, family 4, subfamily F, polypeptide 3; cytochrome P450, subfamily IVF, polypeptide 3 (leukotriene B4 omega hydroxylase); Cytochrome P450-LTB-omega; Docosahexaenoic acid omega-hydroxylase CYP4F3; leukotriene B4 omega hydroxylase; Leukotriene-B(4) 20-monooxygenase 2; Leukotriene-B(4) omega-hydroxylase 2; leukotriene-B4 20-monooxygenase
基因别名: CPF3; CYP4F; CYP4F3; LTB4H
UniProt ID: (Human) Q08477
Entrez Gene ID: (Human) 4051
