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Caspase 6 (Cleaved Asp162) Antibody (PA5-119529) in IHC (P)
Immunohistochemistry of Caspase 6 (Cleaved Asp162) in paraffin-embedded rat esophagus. Sample was treated for antigen retrieval with Citrate buffer (pH 6.0, 15 min) and incubated with polyclonal Caspase 6 (Cleaved Asp162) antibody (Product # PA5-119529) at a dilution of 1:1000.
产品信息
PA5-119529
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Caspase 6 (cleaved Asp162). The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2913103
产品详细信息
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
靶标信息
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apoptotic protease Mch-2; CASP-6; caspase 6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; MCH2
基因别名: CASP-6; CASP6; MCH2
UniProt ID: (Human) P55212, (Mouse) O08738
Entrez Gene ID: (Human) 839, (Mouse) 12368, (Rat) 83584
proteolysis
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
epithelial cell differentiation
regulation of apoptotic process
lens development in camera-type eye
acute inflammatory response to non-antigenic stimulus
response to heat
response to glucose
response to organic substance
response to metal ion
response to iron ion
response to organonitrogen compound
response to gamma radiation
response to estradiol
response to testosterone
response to cytokine
response to hydrogen peroxide
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of retinal cell programmed cell death
