Invitrogen

Complement Factor H Monoclonal Antibody (OX-24)

Complement Factor H Antibody in ELISA (ELISA)

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Complement Factor H Antibody (MA1-70057) in ELISA

Proceedings of the National Academy of Sciences of the United States of America 2021 - Fig. 4. HDM-FH ameliorates glomerular C3 in hFH-FHR5mut mice. ( A ) Representative glomerular images and ( B ) staining scores for C3b/iC3b/C3c, C3d, FHR5mut, FH, IgG, and properdin in male hFH-FHR5mut mice treated with either AAV-GFP ( n = 5, black dots) or AAV-HDM-FH ( n = 7). Bars denote the median, and whiskers denote the interquartile range. * P = 0.0013, derived from Mann-Whitney U test. Plasma hF... View More

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产品信息

MA1-70057

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

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流式细胞分析 (Flow)

1 µg/1 million cells

酶联免疫吸附实验 (ELISA)

1:40,000

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免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

OX-24

抗原

Human complement Factor H.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1073850

产品详细信息

MA1-70057 detects Complement Factor H in human samples.

MA1-70057 has been successfully used in flow cytometry, ELISA, immunoprecipitation and Western blot procedures.

The MA1-70057 immunogen is human complement Factor H.

Store at 4ºC. For long term storage, aliquot and freeze unused portion at -20ºC in volumes appropriat for single usage. Avoid freeze/thaw cycles.

靶标信息

Factor H is a serum protein acting as an inhibitor in the complement activation system. I activates the C3/C5 convertase by dissociating its subunits and also acts as a cofactor for the enzyme activity of Factor I.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.

Proceedings of the National Academy of Sciences of the United States of America

Malik TH,Gitterman DP,Lavin DP,Lomax-Browne HJ,Hiemeyer EC,Moran LB,Boroviak K,Cook HT,Gilmore AC,Mandwie M,Ahmad A,Alexander IE,Logan GJ,Marchbank KJ,Bradley A,Pickering MC

Published figure using Complement Factor H monoclonal antibody (Product # MA1-70057) in ELISA

Tue Mar 30 00:00:00 UTC 2021

Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.

Proceedings of the National Academy of Sciences of the United States of America

Malik TH,Gitterman DP,Lavin DP,Lomax-Browne HJ,Hiemeyer EC,Moran LB,Boroviak K,Cook HT,Gilmore AC,Mandwie M,Ahmad A,Alexander IE,Logan GJ,Marchbank KJ,Bradley A,Pickering MC

Published figure using Complement Factor H monoclonal antibody (Product # MA1-70057) in ELISA

Tue Mar 30 00:00:00 UTC 2021

Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice.

Frontiers in immunology

Kamala O,Malik TH,Hallam TM,Cox TE,Yang Y,Vyas F,Luli S,Connelly C,Gibson B,Smith-Jackson K,Denton H,Pappworth IY,Huang L,Kavanagh D,Pickering MC,Marchbank KJ

MA1-70057 was used in ELISA to enhance complement regulation in vivo and support the application of this approach as a novel treatment strategy in diseases such as C3G.

Mon Feb 07 00:00:00 UTC 2022

Defining the Glycosaminoglycan Interactions of Complement Factor H-Related Protein 5.

Journal of immunology (Baltimore, Md. : 1950)

Gyapon-Quast F,Goicoechea de Jorge E,Malik T,Wu N,Yu J,Chai W,Feizi T,Liu Y,Pickering MC

MA1-70057 was used in Western Blotting to investigate FHR-5 in glomerulonephritis.

Thu Jul 15 00:00:00 UTC 2021

Complement Genetic Variants and FH Desialylation in S. pneumoniae-Haemolytic Uraemic Syndrome.

Frontiers in immunology

Gómez Delgado I,Corvillo F,Nozal P,Arjona E,Madrid Á,Melgosa M,Bravo J,Szilágyi Á,Csuka D,Veszeli N,Prohászka Z,Sánchez-Corral P

MA1-70057 was used in Western Blotting to conclude that aHUS-risk variants in the CFH-CFHR3-CFHR1 region could also contribute to disease-predisposition to SP-HUS, and that transient desialylation of complement FH by the pneumococcal neuraminidase may have a role in disease pathogenesis.

Mon Sep 20 00:00:00 UTC 2021

生物信息学

蛋白别名: adrenomedullin binding protein; age-related maculopathy susceptibility 1; beta-1-H-globulin; beta-1H; Complement factor H; complement factor H, isoform b; factor H; factor H-like 1; FHL1 antibody; H factor 1; H factor 1 (complement); H factor 2 (complement); HGNC:4883; MGC88246; RP1-177P10.1

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基因别名: AHUS1; AMBP1; ARMD4; ARMS1; CFH; CFHL3; FH; FHL1; HF; HF1; HF2; HUS

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UniProt ID: (Human) P08603

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Entrez Gene ID: (Human) 3075

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功能

protein binding heparin binding heparan sulfate proteoglycan binding

参与通路

complement activation complement activation, alternative pathway regulation of complement activation