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Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This antibody will react with all forms of Cyclin L b (cyclin L1b and cyclin L2b). Cross reactivity with Cyclin L beta proteins from other sources is unknown.
FUS/TLS was originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintenance of healthy cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cyclin Ania-6a; cyclin L ania-6a; cyclin L gamma; Cyclin-L; Cyclin-L1
基因别名: 2610030E23Rik; Ania-6a; ANIA6A; AU018493; BM-001; Ccn1; Ccnl; CCNL1; PRO1073; UNQ530/PRO1073
UniProt ID: (Human) Q9UK58, (Mouse) Q52KE7, (Rat) Q5U364
Entrez Gene ID: (Human) 57018, (Mouse) 56706, (Rat) 114121