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DHCR24 Antibody (PA5-27944) in IHC (P)
DHCR24 Polyclonal Antibody detects Seladin 1 protein at cytoplasm on rat adrenal gland by immunohistochemical analysis. Sample: Paraffin-embedded rat adrenal gland. DHCR24 Polyclonal Antibody (Product # PA5-27944) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-27944
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 55 and 358 of Human Seladin 1
偶联物
形式
Liquid
浓度
1.29 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545420
产品详细信息
Recommended positive controls: A431, H1299, mouse brain.
Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (82%), Xenopus laevis (81%), Pig (95%), Chicken (80%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 24-dehydrocholesterol reductase; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol Delta-24-reductase; Delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; Diminuto/dwarf1 homolog; seladin 1; Seladin-1; selective AD indicator 1
基因别名: DCE; DHCR24; KIAA0018; Nbla03646; seladin-1; SELADIN1
UniProt ID: (Human) Q15392, (Rat) Q5BQE6
Entrez Gene ID: (Human) 1718, (Rat) 298298
delta24(24-1) sterol reductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
enzyme binding
peptide antigen binding
delta24-sterol reductase activity
flavin adenine dinucleotide binding
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity
reductase
cholesterol biosynthetic process
apoptotic process
response to oxidative stress
cell cycle arrest
Ras protein signal transduction
protein localization
negative regulation of cell proliferation
response to hormone
tissue development
male genitalia development
plasminogen activation
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
amyloid precursor protein catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
skin development
oxidation-reduction process
membrane organization
regulation of neuron death
steroid metabolic process
cholesterol metabolic process
sterol metabolic process
