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DHRS4 Antibody (PA5-115119) in ICC/IF
Immunocytochemistry analysis of DHRS4 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115119) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115119
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DHRS4(Accession Q9BTZ2), corresponding to amino acid residues C209-D259.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899755
产品详细信息
Antibody detects endogenous levels of total DHRS4.
靶标信息
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: carbonyl reductase; CR; DCR-AKL; dehydrogenase/reductase (SDR family) member 4 like 2A; Dehydrogenase/reductase SDR family member 4; NADP-retinol dehydrogenase; NADPH-dependent carbonyl reductase; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase; NDRD; NRDR; Peroxisomal short-chain alcohol dehydrogenase; PH PSCD; PHCR; Protein SDR25C2; PSCD; SCAD-SRL; Short chain dehydrogenase/reductase family 25C member 2; short chain dehydrogenase/reductase family 25C, member 1; short chain dehydrogenase/reductase family 25C, member 2; Short-chain dehydrogenase/reductase family member 4
基因别名: AI043103; AI790593; CR; D14Ucla2; DHRS4; mouNRDR; NDRD; NRDR; PHCR; PSCD; RRD; SCAD-SRL; SDR-SRL; SDR25C1; SDR25C2; UNQ851/PRO1800
UniProt ID: (Human) Q9BTZ2, (Rat) Q8VID1, (Mouse) Q99LB2
Entrez Gene ID: (Human) 10901, (Rat) 266686, (Mouse) 28200
3-keto sterol reductase activity
carbonyl reductase (NADPH) activity
receptor binding
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
alcohol dehydrogenase [NAD(P)+] activity
NADP-retinol dehydrogenase activity
retinal dehydrogenase activity
oxidoreductase activity
dehydrogenase
