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NeoBiotechnologies
Desmocollin-2/3 Recombinant Mouse Monoclonal Antibody (DSC2/9165R)
产品信息
1824-RBM4-P1ABX
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
DSC2/9165R
抗原
Recombinant full-length human DSC2 protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
Positive Control:HeLa cells. Human esophagus or skin tissue.
Cellular Location: Cell surface
靶标信息
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARVC10; ARVD10; Cadherin family member 2; Cadherin family member 3; CDHF5; CDHF6; CMD1BB; Desmocollin-2; Desmocollin-3; Desmocollin-4; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; HDGC; HT-CP; PVA
基因别名: ARVD11; CDHF2; CDHF3; DG2; DGII/III; DSC; DSC1; DSC2; DSC3; DSC4; HT-CP
UniProt ID: (Human) Q02487, (Human) Q14574
Entrez Gene ID: (Human) 1824, (Human) 1825
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
cellular response to starvation
cardiac muscle cell-cardiac muscle cell adhesion
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
