Product References
Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling.
Oncogene
Hasegawa Y,Takahashi M,Ariki S,Asakawa D,Tajiri M,Wada Y,Yamaguchi Y,Nishitani C,Takamiya R,Saito A,Uehara Y,Hashimoto J,Kurimura Y,Takahashi H,Kuroki Y
MA5-13697 was used in immunoprecipitation and western blot to study the role of impaired EGF binding to EGFR in the mechanism by which surfactant protein D inhibits the progression of lung cancer
Thu Feb 12 00:00:00 UTC 2015
mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes.
Science signaling
Chou CK,Lee HH,Tsou PH,Chen CT,Hsu JM,Yamaguchi H,Wang YN,Lee HJ,Hsu JL,Lee JF,Kameoka J,Hung MC
MA5-13697 was used in ChIP assay to develop a novel flow-proteomic methodology for the detection of individual signaling complex protein-protein interactions in crude cell/tissue lysates
Tue Mar 04 00:00:00 UTC 2014
PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2.
Cell cycle (Georgetown, Tex.)
Kuo HY,Huang YS,Tseng CH,Chen YC,Chang YW,Shih HM,Wu CW
MA5-13697 was used in ChIP assay to study the suppression of nuclear EGFR-mediated transcriptional activation of MMP2 by PML that represses lung cancer metastasis
Mon Aug 31 00:00:00 UTC 2015
Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.
American journal of translational research
Huo L,Li CW,Huang TH,Lam YC,Xia W,Tu C,Chang WC,Hsu JL,Lee DF,Nie L,Yamaguchi H,Wang Y,Lang J,Li LY,Chen CH,Mishra L,Hung MC
MA5-13697 was used in western blot to study the role of EGFR in regulating the Keap1/Nrf2 cascade
Wed Jan 28 00:00:00 UTC 2015
The PML isoform IV is a negative regulator of nuclear EGFR's transcriptional activity in lung cancer.
Carcinogenesis
Kuo HY,Chen YC,Chang HY,Jeng JC,Lin EH,Pan CM,Chang YW,Wang ML,Chou YT,Shih HM,Wu CW
MA5-13697 was used in Immunoprecipitation to suggest that Promyelocytic leukemia protein isoform IV interacts with nuclear epidermal growth factor receptor (EGFR) upon EGFR activation and represses the transcription of nEGFR target genes such as cyclin D1.
Thu Aug 01 00:00:00 UTC 2013
Monitoring the size and lateral dynamics of ErbB1 enriched membrane domains through live cell plasmon coupling microscopy.
PloS one
Rong G,Reinhard BM
MA5-13697 was used in immunocytochemistry to study the dynamics of ErbB1 enriched membrane domains using live cell plasmon coupling microscopy
Fri Aug 03 00:00:00 UTC 2012
A Miniaturized Ligand Binding Assay for EGFR.
International journal of proteomics
Schwenk JM,Poetz O,Zeillinger R,Joos TO
MA5-13697 was used in ELISA to develop a miniaturized ligand binding assay for EGFR
Thu Aug 23 00:00:00 UTC 2012
Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity.
Cell death & disease
Siegemund M,Pollak N,Seifert O,Wahl K,Hanak K,Vogel A,Nussler AK,Göttsch D,Münkel S,Bantel H,Kontermann RE,Pfizenmaier K
MA5-13697 was used in immunoprecipitation to develop targeted dimerized single-chain TRAIL fusion proteins displaying markedly increased anti-tumor activity
Thu Apr 12 00:00:00 UTC 2012
Receptor tyrosine kinase inhibitor profiling using bead-based multiplex sandwich immunoassays.
Methods in molecular biology (Clifton, N.J.)
Pötz O,Schneiderhan-Marra N,Henzler T,Herget T,Joos TO
MA5-13697 was used in blocking or activating experiment to develop a bead-based sandwich immunoassay for the profiling of receptor tyrosine kinase inhibitors
Thu Jan 26 00:00:00 UTC 2012
Quantitative assays for the measurement of HER1-HER2 heterodimerization and phosphorylation in cell lines and breast tumors: applications for diagnostics and targeted drug mechanism of action.
Breast cancer research : BCR
DeFazio-Eli L,Strommen K,Dao-Pick T,Parry G,Goodman L,Winslow J
MA5-13697 was used in immunoprecipitation to investigate the state of HER1-HER2 interaction and modification in cell lines and tumors
Fri Apr 15 00:00:00 UTC 2011
EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.
Cancer letters
Zhu H,Cao X,Ali-Osman F,Keir S,Lo HW
MA5-13697 was used in immunoprecipitation to study the kinase activity-independent binding of EGRF and EGFRvIII to PUMA in glioblastoma cells and the significance for resistance to anti-tumor drugs
Sun Aug 01 00:00:00 UTC 2010
High speed digital protein interaction analysis using microfluidic single molecule detection system.
Lab on a chip
Chou CK,Jing N,Yamaguchi H,Tsou PH,Lee HH,Chen CT,Wang YN,Hong S,Su C,Kameoka J,Hung MC
MA5-13697 was used in western blot to study the use of a microfluidic single molecule detection system for the rapid analysis of protein interactions
Wed Jul 21 00:00:00 UTC 2010
Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium.
Journal of cellular physiology
Qi H,Zheng X,Yuan X,Pflugfelder SC,Li DQ
MA5-13697 was used in immunohistochemistry to study the expression pattern of stem cells in the bulbar conjunctival epithelium
Fri Oct 01 00:00:00 UTC 2010
IL-24 is expressed during wound repair and inhibits TGFalpha-induced migration and proliferation of keratinocytes.
Experimental dermatology
Poindexter NJ,Williams RR,Powis G,Jen E,Caudle AS,Chada S,Grimm EA
MA5-13697 was used in immunoprecipitation to study the role of IL-24 in wound repair and its inhibitory effect on TGFalpha-induced migration and proliferation of keratinocytes
Sun Aug 01 00:00:00 UTC 2010
Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity.
The Journal of biological chemistry
Ahmed IS,Rohe HJ,Twist KE,Craven RJ
MA5-13697 was used in immunocytochemistry to investigate the association between progesterone receptor membrane component 1 and epidermal growth factor receptor and its effect on erlotinib sensitivity
Fri Aug 06 00:00:00 UTC 2010
Intracellular MUC1 peptides inhibit cancer progression.
Clinical cancer research : an official journal of the American Association for Cancer Research
Bitler BG,Menzl I,Huerta CL,Sands B,Knowlton W,Chang A,Schroeder JA
MA5-13697 was used in immunoprecipitation to study the anti-tumor activity of cell-permeant peptides designed to block MUC1 interactions with beta-catenin and EGFR
Thu Jan 01 00:00:00 UTC 2009
EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer.
International journal of cancer
Zhang Y,Su H,Rahimi M,Tochihara R,Tang C
MA5-13697 was used in western blot to study the ability of EGFRvIII to promote estrogen-independent growth in breast cancer cell lines
Sun Nov 01 00:00:00 UTC 2009
EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2.
Molecular biology of the cell
Klessner JL,Desai BV,Amargo EV,Getsios S,Green KJ
MA5-13697 was used in western blot to examine the role of EGFR and ADAMs in the endocytic trafficking of the desmosomal cadherin desmoglein 2
Thu Jan 01 00:00:00 UTC 2009
Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib.
Cancer research
Gilmer TM,Cable L,Alligood K,Rusnak D,Spehar G,Gallagher KT,Woldu E,Carter HL,Truesdale AT,Shewchuk L,Wood ER
MA5-13697 was used in immunoprecipitation to investigate the effect of lapatinib on cell proliferation regulated by EGFR/HER2
Tue Jan 15 00:00:00 UTC 2008
Ligand release-independent transactivation of epidermal growth factor receptor by transforming growth factor-beta involves multiple signaling pathways.
Oncogene
Joo CK,Kim HS,Park JY,Seomun Y,Son MJ,Kim JT
MA5-13697 was used in immunoprecipitation to examine the involvement of epidermal growth factor receptor in transforming growth factor-beta signaling pathways
Thu Jan 24 00:00:00 UTC 2008
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation.
Molecular biology of the cell
Umebayashi K,Stenmark H,Yoshimori T
MA5-13697 was used in immunoprecipitation to study the role of Ubc4/5 and c-Cbl in the polyubiquitination and degradation of internalized EGFR
Fri Aug 01 00:00:00 UTC 2008
Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
Cancer research
Yamasaki F,Johansen MJ,Zhang D,Krishnamurthy S,Felix E,Bartholomeusz C,Aguilar RJ,Kurisu K,Mills GB,Hortobagyi GN,Ueno NT
MA5-13697 was used in immunoprecipitation to study the mechanism of acquired resistance to erlotinib in epidermoid cancer cells
Fri Jun 15 00:00:00 UTC 2007
Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition.
British journal of cancer
Xu W,Soga S,Beebe K,Lee MJ,Kim YS,Trepel J,Neckers L
MA5-13697 was used in immunoprecipitation to study the sensitivity of EGFR and ErbB2 exon 20 insertion mutants to Hsp90 inhibition
Mon Sep 17 00:00:00 UTC 2007
Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America
Crotty T,Cai J,Sakane F,Taketomi A,Prescott SM,Topham MK
MA5-13697 was used in immunoprecipitation to study the role of PKC in the mechanism by which diacylglycerol kinase-delta regulates EGFR signaling
Tue Oct 17 00:00:00 UTC 2006
Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.
Journal of cellular biochemistry
Lo HW,Ali-Seyed M,Wu Y,Bartholomeusz G,Hsu SC,Hung MC
MA5-13697 was used in immunoprecipitation to study the mechanism of EGFR nuclear-cytoplasmic transport
Tue Aug 15 00:00:00 UTC 2006
Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling.
Molecular pharmacology
Martin NP,Mohney RP,Dunn S,Das M,Scappini E,O'Bryan JP
MA5-13697 was used in immunoprecipitation to study the mechanism by which the endocytic scaffold protein intersectin regulates EGFR degradation and signaling
Wed Nov 01 00:00:00 UTC 2006
The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3.
The Journal of biological chemistry
Funes M,Miller JK,Lai C,Carraway KL,Sweeney C
MA5-13697 was used in immunocytochemistry to study the role of ErbB2 and ErbB3 in the mechanism by which Muc4 potentiates neuregulin signaling
Fri Jul 14 00:00:00 UTC 2006
Functional effects of glycosylation at Asn-579 of the epidermal growth factor receptor.
Biochemistry
Whitson KB,Whitson SR,Red-Brewer ML,McCoy AJ,Vitali AA,Walker F,Johns TG,Beth AH,Staros JV
MA5-13697 was used in flow cytometry to study the functional effects of N-glycosylation of Asn-579 of EGFR
Tue Nov 15 00:00:00 UTC 2005
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.
Cancer research
Wood ER,Truesdale AT,McDonald OB,Yuan D,Hassell A,Dickerson SH,Ellis B,Pennisi C,Horne E,Lackey K,Alligood KJ,Rusnak DW,Gilmer TM,Shewchuk L
MA5-13697 was used in immunoprecipitation to conduct the structural analysis of the binding of epidermal growth factor receptor to GW572016
Wed Sep 15 00:00:00 UTC 2004
Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK.
Molecular biology of the cell
Kansra S,Stoll SW,Johnson JL,Elder JT
MA5-13697 was used in immunoprecipitation to investigate the mechanism of ERK autocrine activation in normal human keratinocytes
Wed Sep 01 00:00:00 UTC 2004
Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity.
The Journal of biological chemistry
Barzilay E,Ben-Califa N,Supino-Rosin L,Kashman Y,Hirschberg K,Elazar Z,Neumann D
MA5-13697 was used in immunoprecipitation to study a co-purifying contaminant of geldanamycin preparations as the component inhibiting intracellular trafficking
Fri Feb 20 00:00:00 UTC 2004
Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization.
Proceedings of the National Academy of Sciences of the United States of America
Schmidt MHH,Furnari FB,Cavenee WK,Bögler O
MA5-13697 was used in western blot to study the role of EGFR signaling intensity in determining intracellular protein interactions, ubiquitination, and internalization
Tue May 27 00:00:00 UTC 2003
1,25-Dihydroxyvitamin D down-regulates cell membrane growth- and nuclear growth-promoting signals by the epidermal growth factor receptor.
The Journal of biological chemistry
Cordero JB,Cozzolino M,Lu Y,Vidal M,Slatopolsky E,Stahl PD,Barbieri MA,Dusso A
MA5-13697 was used in immunoprecipitation to study the down regulatory effects of 1,25-dihydroxyvitamin D on EGFR membrane trafficing and growth signaling
Fri Oct 11 00:00:00 UTC 2002
Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells.
Journal of the National Cancer Institute
Bergmann-Leitner ES,Bennett TA,Hacker NF,Stromberg K,Stetler-Stevenson WG
MA5-13697 was used in immunoprecipitation to study the role of EGFR signaling in the invasiveness of ovarian carcinoma cells
Wed Sep 19 00:00:00 UTC 2001
Tyrosine-phosphorylated plakoglobin is associated with desmogleins but not desmoplakin after epidermal growth factor receptor activation.
The Journal of biological chemistry
Gaudry CA,Palka HL,Dusek RL,Huen AC,Khandekar MJ,Hudson LG,Green KJ
MA5-13697 was used in immunoprecipitation to study the effects of EGFR activation on the association of tyrosine phosphorylated plakoglobin with desmogleins and desmoplakin
Fri Jul 06 00:00:00 UTC 2001
Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer.
Cancer research
Tang CK,Gong XQ,Moscatello DK,Wong AJ,Lippman ME
MA5-13697 was used in immunoprecipitation to study the role of the constitutively active EGFR vIII variant in the proliferation and tumorigenicity of human breast cancer
Thu Jun 01 00:00:00 UTC 2000
Intracellular retention and degradation of the epidermal growth factor receptor, two distinct processes mediated by benzoquinone ansamycins.
The Journal of biological chemistry
Supino-Rosin L,Yoshimura A,Yarden Y,Elazar Z,Neumann D
MA5-13697 was used in immunoprecipitation to study the effect of the benzoquinone ansamycins on the intracellular retention and degradation of EGFR
Fri Jul 21 00:00:00 UTC 2000
A sandwich type acridinium-linked immunosorbent assay (ALISA) detects soluble ErbB1 (sErbB1) in normal human sera.
Journal of immunological methods
Baron AT,Lafky JM,Connolly DC,Peoples J,O'Kane DJ,Suman VJ,Boardman CH,Podratz KC,Maihle NJ
MA5-13697 was used in western blot to develop an acridium-linked immunosorbent assay for measuring soluble ErbB1 in human serum
Thu Oct 01 00:00:00 UTC 1998
