Invitrogen

FGFR5 Polyclonal Antibody

FGFR5 Antibody in Immunohistochemistry (Frozen) (IHC (F))

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FGFR5 Antibody (PA5-47218) in IHC (F)

Immunohistochemical analysis of FGFR5 in perfusion fixed frozen sections of mouse lung. Samples were incubated in FGFR5 polyclonal antibody (Product # PA5-47218) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane and cytoplasm of al... View More

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产品信息

PA5-47218

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1 µg/mL

免疫组化（冰冻） (IHC (F))

5-15 µg/mL

产品规格

种属反应

Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Mouse myeloma cell line NS0-derived recombinant mouse FGF R5 beta Ala21-Pro374

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2606312

产品详细信息

In Western blots, less than 5% cross-reactivity with recombinant human (rh) FGF R1 alpha (IIIb), recombinant mouse (rm) FGF R2 beta (IIIc), rmFGF R3 alpha (IIIb), rhFGF R3 alpha (IIIc), rhFGF R1 beta (IIIc), rmFGF R2 beta (IIIb), rhFGF R1 alpha (IIIc), rmFGF R2 alpha (IIIc), rhFGF R1 beta (IIIb), rmFGF R2 alpha (IIIb), rmFGF R2, and rmFGF R4 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

靶标信息

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.

仅用于科研。不用于诊断过程。未经明确授权不得转售。