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产品信息
MA5-15542
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
7H4B7
抗原
Purified recombinant fragment of FOXA2 expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_10979228
产品详细信息
MA5-15542 targets FOXA2 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15542 immunogen is purified recombinant fragment of FOXA2 expressed in E. Coli.
MA5-15542 detects FOXA2 which has a predicted molecular weight of approximately 48kDa.
靶标信息
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3 beta (winged helix transcription factor); hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; WHN
基因别名: FOXA2; Hnf-3b; HNF3-beta; HNF3B; HNF3beta; Tcf-3b; TCF3B
UniProt ID: (Human) Q9Y261, (Mouse) P35583
Entrez Gene ID: (Human) 3170, (Mouse) 15376
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein domain specific binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
double-stranded DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
kinase binding
sequence-specific DNA binding
SMAD binding
positive regulation of transcription from RNA polymerase II promoter by glucose
negative regulation of transcription from RNA polymerase II promoter by glucose
in utero embryonic development
ectoderm formation
cell fate specification
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
Notch signaling pathway
multicellular organism development
pattern specification process
adult locomotory behavior
anatomical structure morphogenesis
anterior/posterior pattern specification
dorsal/ventral pattern formation
regulation of gene expression
negative regulation of epithelial to mesenchymal transition
chromatin modification
regulation of lipid metabolic process
regulation of steroid metabolic process
cell differentiation in hindbrain
dorsal/ventral neural tube patterning
signal transduction involved in regulation of gene expression
regulation of blood coagulation
lung development
endocrine pancreas development
somite rostral/caudal axis specification
negative regulation of glucokinase activity
positive regulation of embryonic development
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of smoothened signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
cell development
anatomical structure formation involved in morphogenesis
neuron fate specification
epithelial tube branching involved in lung morphogenesis
lung epithelial cell differentiation
regulation of insulin secretion involved in cellular response to glucose stimulus
connective tissue development
response to interleukin-6
dopaminergic neuron differentiation
primitive streak formation
positive regulation of gastrulation
negative regulation of detection of glucose
covalent chromatin modification
positive regulation of cell-cell adhesion mediated by cadherin
