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产品信息
MA1-10828
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
B7C9
抗原
Purified human Factor XII.
偶联物
形式
Liquid
浓度
1.4 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1074352
产品详细信息
MA1-10828 detects Factor XII heavy chain, from human samples.
MA1-10828 has been successfully used in ELISA and Western blot applications. By Western blot, this antibody detects a ~50 kDa band representing the non-reduced heavy chain of Factor XII from normal human plasma .
The MA1-10828 immunogen is purified human Factor XII.
靶标信息
Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin. An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade. Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it. Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism. The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Beta-factor XIIa part 1; Beta-factor XIIa part 2; Coagulation factor XII; coagulation factor XII (Hageman factor); Coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain; Factor 12; Factor12; HAF; Hageman factor
基因别名: F12; HAE3; HAEX; HAF
UniProt ID: (Human) P00748
Entrez Gene ID: (Human) 2161
plasma kallikrein-kinin cascade
Factor XII activation
blood coagulation, intrinsic pathway
positive regulation of plasminogen activation
protein processing
protein autoprocessing
positive regulation of blood coagulation
zymogen activation
fibrinolysis
innate immune response
response to misfolded protein
positive regulation of fibrinolysis
