Invitrogen

GABRA5 Polyclonal Antibody

GABRA5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GABRA5 Antibody (PA5-31163) in IHC (P)

GABRA5 Polyclonal Antibody detects GABA A Receptor alpha 5 protein at cytoplasm by immunohistochemical analysis. Sample: Paraffin-embedded mouse cerebellum. GABA A Receptor alpha 5 stained by GABRA5 Polyclonal Antibody (Product # PA5-31163) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

GABRA5 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-31163

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1000

产品规格

种属反应

Human, Mouse

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 142 and 379 of Human GABA A Receptor alpha 5

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.21 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol, 1% BSA

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2548637

产品详细信息

Recommended positive controls: GABRA5-transfected 293T.

Predicted reactivity: Mouse (100%), Rat (100%), Bovine (98%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

GABRA5 is a part of GABA, a major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Amyloid-Beta_1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells.

Molecules (Basel, Switzerland)

Calvo-Flores Guzmán B,Kim S,Chawdhary B,Peppercorn K,Tate WP,Waldvogel HJ,Faull RL,Montgomery J,Kwakowsky A

PA5-31163 was used in Immunohistochemistry to show that hippocampal injection of Aβ1-42 is sufficient to induce cognitive deficits 7 days post-injection.

Thu Feb 06 00:00:00 UTC 2020

Amyloid-Beta_1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells.

Molecules (Basel, Switzerland)

Calvo-Flores Guzmán B,Kim S,Chawdhary B,Peppercorn K,Tate WP,Waldvogel HJ,Faull RL,Montgomery J,Kwakowsky A

PA5-31163 was used in Immunohistochemistry to show that hippocampal injection of Aβ1-42 is sufficient to induce cognitive deficits 7 days post-injection.

Thu Feb 06 00:00:00 UTC 2020

GABA_A Receptors Are Well Preserved in the Hippocampus of Aged Mice.

eNeuro

Palpagama TH,Sagniez M,Kim S,Waldvogel HJ,Faull RL,Kwakowsky A

PA5-31163 was used in Western Blotting to show, that GABAA Receptors are well preserved in ageing mice.Western blotting and immunohistochemistry were used.

Mon Mar 02 00:00:00 UTC 2020

GABA_A Receptors Are Well Preserved in the Hippocampus of Aged Mice.

eNeuro

Palpagama TH,Sagniez M,Kim S,Waldvogel HJ,Faull RL,Kwakowsky A

PA5-31163 was used in Western Blotting to show, that GABAA Receptors are well preserved in ageing mice.Western blotting and immunohistochemistry were used.

Mon Mar 02 00:00:00 UTC 2020

Biology of sex differences

Pandya M,Palpagama TH,Turner C,Waldvogel HJ,Faull RL,Kwakowsky A

Published figure using GABRA5 polyclonal antibody (Product # PA5-31163) in Western Blot

Mon Jan 14 00:00:00 UTC 2019

生物信息学

蛋白别名: GABA(A) receptor; GABA(A) receptor subunit alpha-5; GABAA receptor alpha5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; Gamma-aminobutyric acid receptor subunit alpha-5; ligand-gated ion channel subunit

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基因别名: A230018I05Rik; GABRA5

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UniProt ID: (Human) P31644, (Mouse) Q8BHJ7

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Entrez Gene ID: (Human) 2558, (Mouse) 110886

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功能

receptor activity GABA-A receptor activity transporter activity extracellular ligand-gated ion channel activity chloride channel activity GABA receptor binding ion channel activity protein binding ligand-gated ion channel

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