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产品信息
OSC00174W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from the n-terminal region of human GARP conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: GARP.
靶标信息
Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. GARPs are characterized by six repeated motifs of: V V E K K N/E E. These repeat motifs help form an alpha-helix structure. The function(s) of GARP have not been fully characterized, but studies have suggested that GARP helps limit cGMP turnover by inhibiting phosphodiesterase activity. To date, there have been two splice variants characterized: GARP1 (full-length GARP) and GARP2 (truncated GARP). GARP also interacts with part of the larger cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel found in the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cng channel; CNG channel 4; CNG channel beta-1; CNG-4; Cyclic nucleotide-gated cation channel 4; cyclic nucleotide-gated cation channel beta-1; Cyclic nucleotide-gated cation channel gamma; Cyclic nucleotide-gated cation channel modulatory subunit; cyclic nucleotide-gated channel beta subunit 1; Cyclic nucleotide-gated channel beta-1; GARP; Glutamic acid-rich protein; glutamic-acid-rich protein
基因别名: CNCG2; CNCG3L; CNCG4; CNG4; CNGB1; CNGB1B; GAR1; GARP; GARP2; Gm1959; RCNC2; RCNCb; RCNCbeta; RP45
UniProt ID: (Human) Q14028, (Mouse) E1AZ71
Entrez Gene ID: (Human) 1258, (Rat) 83686, (Mouse) 333329
intracellular cAMP activated cation channel activity
intracellular cGMP activated cation channel activity
voltage-gated potassium channel activity
protein binding
ligand-gated ion channel activity
cAMP binding
cGMP binding
intracellular cyclic nucleotide activated cation channel activity
cyclic nucleotide-gated ion channel activity
ligand-gated ion channel
retina homeostasis
transport
cation transport
visual perception
sensory perception of smell
rhodopsin mediated signaling pathway
regulation of rhodopsin mediated signaling pathway
protein localization to organelle
photoreceptor cell outer segment organization
regulation of membrane potential
photoreceptor cell maintenance
detection of light stimulus involved in visual perception
potassium ion transmembrane transport
phototransduction
phototransduction, visible light
ion transmembrane transport
protein heterotetramerization
regulation of cytosolic calcium ion concentration
regulation of ion transmembrane transport
