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GBA2 Antibody (PA5-88792) in WB
Western blot analysis of GBA2 in extracts of various cell lines. Samples were incubated with GBA2 Polyclonal antibody (Product # PA5-88792) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-88792
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 708-927 of human GBA2 (NP_0659951)
偶联物
形式
Liquid
浓度
0.87 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805134
产品详细信息
Immunogen sequence: AQDIQDKFSS ILSRGQEAYE RLLWNGRYYN YDSSSRPQSR SVMSDQCAGQ WFLKACGLGE GDTEVFPTQH VVRALQTIFE LNVQAFAGGA MGAVNGMQPH GVPDKSSVQS DEVWVGVVYG LAATMIQEGL TWEGFQTAEG CYRTVWERLG LAFQTPEAYC QQRVFRSLAY MRPLSIWAMQ LALQQQQHKK ASWPKVKQGT GLRTGPMFGP KEAMANLSPE; Positive Samples: U-87MG, Mouse kidney, Mouse heart; Cellular Location: Cytoplasmic side, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein
靶标信息
Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3.2.1.45; Beta-glucocerebrosidase 2; Beta-glucosidase 2; bile acid; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; glucosidase, beta (bile acid) 2; Glucosylceramidase 2; NLGase; Non-lysosomal cholesterol glycosyltransferase; Non-lysosomal galactosylceramidase; Non-lysosomal glucosylceramidase; Non-lysosomal glycosylceramidase
基因别名: AD035; F630034E04; GBA2; KIAA1605; NLGase; SPG46
UniProt ID: (Human) Q9HCG7, (Mouse) Q69ZF3
Entrez Gene ID: (Human) 57704, (Mouse) 230101
